{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T14:01:10Z","timestamp":1780149670400,"version":"3.54.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Breast cancer is the leading cause of cancer\u2010related death in women worldwide. Hormone receptor\u2010positive\/human epidermal growth factor receptor 2\u2010negative (HR+\/HER2\u2212) metastatic breast cancer (MBC) represents the most common subtype. Cyclin\u2010dependent kinase 4\/6 (CDK4\/6) inhibitors combined with endocrine therapy (ET) constitute standard first\u2010line treatment, yet evidence comparing ribociclib and palbociclib in peri\u2212\/premenopausal patients remains limited. This study aimed to evaluate and compare the real\u2010world efficacy and safety profiles of ribociclib versus palbociclib in combination with ET in this patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This multicenter, retrospective study included 267 peri\u2212\/premenopausal patients with HR+\/HER2\u2212 MBC treated with palbociclib (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200986) or ribociclib (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009181) plus ET across five centers in Turkey between 2020 and 2024. Primary end points were progression\u2010free survival (PFS) and overall survival (OS); secondary end points included objective response rate (ORR) and safety. Survival analyses used Kaplan\u2013Meier and Cox regression methods using R software; adverse events were graded per Common Terminology Criteria for Adverse Events (CTCAE) v5.0.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age was 42.96\u2009years. Median follow\u2010up was 19.6\u2009months for palbociclib and 13.3\u2009months for ribociclib (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). No statistically significant differences were observed between palbociclib and ribociclib in median PFS (24.05 vs. 24.41\u2009months; HR: 1.06;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.94) or OS (not reached vs. 41.03\u2009months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.86). The ORR was comparable at 64% for palbociclib and 69% for ribociclib (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.459). Safety profiles were similar; any\u2010grade adverse events occurred in 77.9% of palbociclib and 80.7% of ribociclib patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.600). Neutropenia was the most common toxicity (72.1% palbociclib vs. 74.0% ribociclib). Grade 3\u20134 adverse events occurred in 29.1% of the palbociclib group and 40.3% of the ribociclib group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.074). Subgroup analyses showed consistent treatment effects across age, visceral involvement, and line of therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In real\u2010world peri\u2212\/premenopausal patients with HR+\/HER2\u2212 MBC, ribociclib and palbociclib combined with ET demonstrate comparable efficacy and tolerability. These findings support flexible treatment choice based on individual patient profiles and preferences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/phar.70134","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T04:12:25Z","timestamp":1773893545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of\n                    <scp>CDK4<\/scp>\n                    \/6 Inhibitor\u2010Based Therapy in Premenopausal\n                    <scp>HR<\/scp>\n                    +\/\n                    <scp>HER2<\/scp>\n                    \u2212 Metastatic Breast Cancer: Real World Data From A Multicenter Study"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5757-4705","authenticated-orcid":false,"given":"Hatice","family":"Odaba\u015f","sequence":"first","affiliation":[{"name":"Kartal Dr. Lutfi Kirdar City Hospital, University of 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