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Tumor\u2010directed therapies, such as radiation and antineoplastic agents, have greatly expanded beyond traditional deoxyribonucleic acid (DNA)\u2010damaging agents to encompass pharmacologic agents, such as targeted monoclonal antibodies, kinase inhibitors, and immune activating therapies that may have varying effects on women's fertility. Here, we review the current literature to provide a comprehensive summary on the effect of cancer treatment modalities on female fertility, fertility preservation options in female patients, and the role of pharmacists in oncofertility practice.<\/jats:p>","DOI":"10.1002\/phar.70143","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:29:46Z","timestamp":1778549386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cancer Treatment Modalities and Female Fertility Preservation"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0638-9558","authenticated-orcid":false,"given":"Seonga","family":"Song","sequence":"first","affiliation":[{"name":"Hematology and Oncology NYU Langone Hospital\u2014Long Island  Mineola New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7885-292X","authenticated-orcid":false,"given":"Lilia","family":"Davenport","sequence":"additional","affiliation":[{"name":"Hematology and Oncology Baptist Health South Florida  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0910-9489","authenticated-orcid":false,"given":"Samantha","family":"Paone","sequence":"additional","affiliation":[{"name":"Ambulatory Hematology and Oncology Florina Cancer Center\u2014Northwell Health  Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3576-5789","authenticated-orcid":false,"given":"Jamie","family":"Chin\u2010Hon","sequence":"additional","affiliation":[{"name":"Transplant and Cellular Therapy NYU Langone Health, Perlmutter Cancer Center\u2014Mineola  Mineola New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28854"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon\u20102016\u20100176"},{"key":"e_1_2_10_4_1","unstructured":"Children's Oncology Group (COG) \u201cLong\u2010Term Follow\u2010Up Guidelines (Version 5.0) \u201d (2018)."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.05.009"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24679"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14061912"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2020.0012"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13051209"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.07.009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfy189"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO\u201024\u201002782"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2024.101383"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2022.01.016"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010020\u201005692\u20105"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.04.038"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/frph.2022.812053"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010016\u20102505\u20109"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfz022"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094\u2010016\u20101587\u20109"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.12.016"},{"key":"e_1_2_10_22_1","unstructured":"National Comprehensive Cancer Network (NCCN) \u201cAdolescent and Young Adult (AYA) and Oncology (Version 2.2026) \u201d (2026)."},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181dce339"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.7.3045.bloodjournal8773045"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2014.93"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2021.100276"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010022\u201000413\u2010x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1703481"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019\u20100094"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.0393"},{"key":"e_1_2_10_31_1","doi-asserted-by":"crossref","unstructured":"E. 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