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Female\u2010specific malignancies such as breast, ovarian, endometrial, and cervical cancers exhibit distinct thrombotic profiles driven by hormonal, anatomical, and treatment\u2010related factors. This review summarizes current evidence on CAT in these malignancies, emphasizing chemotherapy\u2010 and hormone\u2010related risk, thromboprophylactic strategies, and pharmacologic considerations in anticoagulant selection. Ovarian cancer carries the highest incidence of venous thromboembolism (VTE), ranging from 5% to 14%, largely due to advanced disease, ascites, and platinum\u2010based chemotherapy. Breast cancer accounts for approximately 15% of all CAT cases, with increased risk observed among patients treated with selective estrogen receptor modulators or cyclin\u2010dependent kinase 4\/6 inhibitors. Endometrial cancer presents a moderate to high risk for CAT, especially in obese patients and those receiving hormonal therapy or radiation. Prophylaxis with low\u2010molecular\u2010weight heparins (LMWHs) or direct oral anticoagulants (DOACs) effectively reduces VTE incidence in high\u2010risk patients. In the API\u2010CAT trial, reduced\u2010dose apixaban (2.5\u2009mg twice daily) was non\u2010inferior to full\u2010dose therapy for extended anticoagulation after 6\u2009months of treatment (2.1% vs. 2.8%; adjusted subhazard ratio, 0.76; 95% Confidence Interval (CI), 0.58\u20130.97;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). Drug\u2013drug interactions with anticoagulants and agents such as doxorubicin, ribociclib, and tamoxifen warrant individualized anticoagulant selection and close monitoring. A patient\u2010centered pharmacotherapeutic approach, supported by multidisciplinary collaboration, is essential to optimize thrombosis prevention and minimize bleeding risk in women with cancer.\n                  <\/jats:p>","DOI":"10.1002\/phar.70149","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T02:58:31Z","timestamp":1776481111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Thrombosis Across Female\u2010Specific Malignancies: From Chemotherapy\u2010Driven Risk to Prophylaxis and Drug Interactions"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0121-5989","authenticated-orcid":false,"given":"Maryam","family":"Aghakouchakzadeh","sequence":"first","affiliation":[{"name":"Tehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6719-4856","authenticated-orcid":false,"given":"Hessam","family":"Kakavand","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacoeconomics, School of Pharmacy Iran University of Medical Sciences  Tehran Iran"},{"name":"Vascular Disease and Thrombosis Research Center Rajaie Cardiovascular Institute  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne J.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Division of Cardiology New York\u2010Presbyterian Hospital\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4156-7279","authenticated-orcid":false,"given":"Melissa","family":"Accordino","sequence":"additional","affiliation":[{"name":"Division of Breast Cancer Oncology New York\u2010Presbyterian Hospital\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-0492","authenticated-orcid":false,"given":"Meghna","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Division of Breast Cancer Oncology New York\u2010Presbyterian Hospital\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8561-7899","authenticated-orcid":false,"given":"Jayant K.","family":"Raikhelkar","sequence":"additional","affiliation":[{"name":"Division of Cardiology New York\u2010Presbyterian Hospital\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1839-3685","authenticated-orcid":false,"given":"Azita 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