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The current dosing approach, informed by population\u2010level data, tends to be simplistically reduced to a \u201cone size fits all\u201d dosing method which only accounts for body weight (i.e., in pediatrics) and end organ function to estimate drug clearance (e.g., estimated glomerular filtration rate); this approach results in substantial variability in observed serum concentrations in acutely ill patients, which can compromise real\u2010world effectiveness and safety. Beta\u2010lactam dose individualization, therefore, defined as a dosing regimen for one patient informed by measured concentrations from that patient, has been recommended in international clinical guidelines. Comprehensive guidance on best practices for beta\u2010lactam dose individualization is lacking. To address this knowledge gap and develop guidance, a multidisciplinary panel of international experts was assembled from the disciplines of infectious diseases, critical care, pharmacometrics, and laboratory medicine, representing both adults and pediatrics. The panel systematically evaluated the literature, using the GRADE approach where feasible, to address broad thematic questions pertaining to whether beta\u2010lactam dose individualization should be pursued, for what indications beta\u2010lactam dose individualization is warranted, and the most critical considerations and best practices for implementation of beta\u2010lactam individualization. The resultant consensus recommendations will equip healthcare professionals caring for acutely ill patients treated with beta\u2010lactam therapy with the evidence and tools necessary to guide optimal use of beta\u2010lactam dose individualization.<\/jats:p>","DOI":"10.1002\/phar.70181","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:32:02Z","timestamp":1784781122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Consensus Guidance for Beta\u2010Lactam Antibiotic Dose Individualization in Acutely Ill Patients: Endorsed by the American College of Clinical Pharmacy, European Society of Clinical Microbiology and Infectious Diseases, European Society of Clinical Microbiology and Infectious Diseases PK\/PD of Anti\u2010Infectives Study Group, Infectious Diseases Society of America, International Association of Therapeutic Drug Monitoring and Clinical Toxicology, Society of Critical Care Medicine, and the Society of Infectious Diseases Pharmacists"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0996-1487","authenticated-orcid":false,"given":"Erin F.","family":"Barreto","sequence":"first","affiliation":[{"name":"Department of Pharmacy Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6705-2225","authenticated-orcid":false,"given":"Erin K.","family":"McCreary","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8447-6836","authenticated-orcid":false,"given":"Rekha","family":"Pai Mangalore","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Alfred Hospital, Bayside Health, Melbourne and School of Translational Medicine &amp; Centre to Impact AMR Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7737-8499","authenticated-orcid":false,"given":"Sonya","family":"Tang Girdwood","sequence":"additional","affiliation":[{"name":"Divisions of Hospital Medicine and Translational and Clinical Pharmacology Cincinnati Children\u2019s Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Arriola","sequence":"additional","affiliation":[{"name":"Pharmacometrics Center of Excellence Midwestern University, Downers Grove Campus  Downers Grove Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Bens","sequence":"additional","affiliation":[{"name":"Personalized Medicine Coalition  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3299-894X","authenticated-orcid":false,"given":"Robert A.","family":"Bonomo","sequence":"additional","affiliation":[{"name":"Cleveland VAMC  Cleveland Ohio USA"},{"name":"Case VA Center for Antimicrobial Resistance and Epidemiology (Case VA CARES)  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9014-1653","authenticated-orcid":false,"given":"Andrea N.","family":"Edginton","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Waterloo  Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-5400","authenticated-orcid":false,"given":"Lisa T.","family":"Hong","sequence":"additional","affiliation":[{"name":"Loma Linda University School of Pharmacy  Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8380-368X","authenticated-orcid":false,"given":"Angela","family":"Huttner","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Geneva University Hospitals and Faculty of Medicine  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1202-3643","authenticated-orcid":false,"given":"Birgit C. 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