{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:50:10Z","timestamp":1791528610793,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The polymyxins, polymyxin B and colistin, are last\u2010line options for the treatment of infections caused by drug\u2010resistant gram\u2010negative organisms. The comparative neurotoxicity of these agents using contemporary dosing is poorly understood. We sought to compare the incidence of neurotoxicity among recipients of polymyxin B or colistin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a single\u2010center, retrospective cohort study of all patients who received colistin or polymyxin B for the treatment of a serious gram\u2010negative infection between March 2016 and April 2020. The primary outcome of interest was treatment\u2010emergent neurotoxicity, defined as new\u2010onset perioral paresthesia, non\u2010oral paresthesia, peripheral neuropathy, seizure, diaphragmatic paralysis, or other neurotoxicity. Bivariate analyses were performed using Fisher's exact test and the Wilcoxon rank\u2010sum test; no multivariable analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 82 patients receiving polymyxin B (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200939) or colistin (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200943) were identified. Neurotoxicity, nearly exclusively paresthesia, was more commonly seen in recipients of polymyxin B (10\/39 evaluable patients, 26%) versus colistin (1\/42 evaluable patients, 2%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Neurotoxicity most commonly developed on the first day of therapy and resolved with discontinuation of therapy or prolongation of the infusion duration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Polymyxin B is associated with significantly more neurotoxicity than colistin in unadjusted analyses. This potential risk should be considered when choosing between these two agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/phar.70202","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:14:16Z","timestamp":1789442056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Neurotoxicity of Polymyxin B and Colistin in Patients With Cancer"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8659-4238","authenticated-orcid":false,"given":"Samuel L.","family":"Aitken","sequence":"first","affiliation":[{"name":"Department of Pharmacy Michigan Medicine  Ann Arbor Michigan USA"},{"name":"Division of Infectious Diseases University of Michigan Medical School  Ann Arbor Michigan USA"},{"name":"Department of Clinical Pharmacy University of Michigan College of Pharmacy  Ann Arbor Michigan USA"},{"name":"Division of Pharmacy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5508-0376","authenticated-orcid":false,"given":"Emily R.","family":"Aboujaoude","sequence":"additional","affiliation":[{"name":"Division of Pharmacy The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"School of Pharmacy D'Youville University  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6323-6211","authenticated-orcid":false,"given":"Jovan","family":"Borjan","sequence":"additional","affiliation":[{"name":"Division of Pharmacy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7510-5470","authenticated-orcid":false,"given":"Frank P.","family":"Tverdek","sequence":"additional","affiliation":[{"name":"Division of Pharmacy The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Department of Pharmacy Fred Hutchinson Cancer Center  Seattle Washington USA"},{"name":"Department of Pharmacy University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.11.025"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae403"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab612"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaf398"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2209"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196204122661505"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.09.010"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw839"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit334"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfs160"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz344"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-024-09759-2"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00300"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2021.1890024"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2024.2348610"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.12.009"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfz158"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.5.5.811"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug 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