{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:39:24Z","timestamp":1781174364354,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T00:00:00Z","timestamp":1390348800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"The Novo Nordisk Foundation"},{"name":"The Lundbeck Foundation"},{"name":"The H\u00f8rslev Foundation"},{"name":"Bj\u00f8rnow Foundation"},{"name":"AJ Andersen Foundation"},{"name":"Jacob and Olga Madsen Foundation"},{"name":"Danish Medical Association Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1002\/phy2.202","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T02:36:09Z","timestamp":1390444569000},"page":"e00202","source":"Crossref","is-referenced-by-count":16,"title":["Lithium induces microcysts and polyuria in adolescent rat kidney independent of cyclooxygenase-2"],"prefix":"10.14814","volume":"2","author":[{"given":"Gitte","family":"Kjaersgaard","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Renal Research; University of Southern Denmark; Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Renal Research; University of Southern Denmark; Odense Denmark"},{"name":"Department of Pathology; Odense University Hospital; Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Marcussen","sequence":"additional","affiliation":[{"name":"Department of Pathology; Odense University Hospital; Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boye L.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Renal Research; University of Southern Denmark; Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,22]]},"reference":[{"key":"10.1002\/phy2.202-BIB0001|phy2202-cit-0001","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/j.1523-1755.2004.00843.x","article-title":"Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells","volume":"66","author":"Belibi","year":"2004","journal-title":"Kidney Int."},{"key":"10.1002\/phy2.202-BIB0002|phy2202-cit-0002","first-page":"F377","article-title":"Segmental synthesis and actions of prostaglandins along the nephron","volume":"253","author":"Bonvalet","year":"1987","journal-title":"Am. J. Physiol."},{"key":"10.1002\/phy2.202-BIB0003|phy2202-cit-0003","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0272-6386(87)80098-7","article-title":"Prevalence, pathogenesis, and treatment of renal dysfunction associated with chronic lithium therapy","volume":"10","author":"Boton","year":"1987","journal-title":"Am. J. Kidney Dis."},{"key":"10.1002\/phy2.202-BIB0004|phy2202-cit-0004","doi-asserted-by":"crossref","first-page":"F12","DOI":"10.1152\/ajprenal.2000.279.1.F12","article-title":"Prostaglandin E receptors and the kidney","volume":"279","author":"Breyer","year":"2000","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1002\/phy2.202-BIB0005|phy2202-cit-0005","doi-asserted-by":"crossref","first-page":"F19","DOI":"10.1152\/ajprenal.00443.2002","article-title":"Key enzymes for renal prostaglandin synthesis: site-specific expression in rodent kidney (rat, mouse)","volume":"285","author":"Campean","year":"2003","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1002\/phy2.202-BIB0006|phy2202-cit-0006","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/BF00656716","article-title":"Lithium-induced uremia in rats - a new model of chronic renal failure","volume":"399","author":"Christensen","year":"1983","journal-title":"Pflugers Arch."},{"key":"10.1002\/phy2.202-BIB0007|phy2202-cit-0007","first-page":"95","article-title":"Functional and structural changes in the rat kidney by long-term lithium treatment","volume":"5","author":"Christensen","year":"1982","journal-title":"Ren. Physiol."},{"key":"10.1002\/phy2.202-BIB0008|phy2202-cit-0008","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1681\/ASN.2010070734","article-title":"alphaENaC-mediated lithium absorption promotes nephrogenic diabetes insipidus","volume":"22","author":"Christensen","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1002\/phy2.202-BIB0009|phy2202-cit-0009","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1148\/radiol.2292020758","article-title":"Chronic lithium nephropathy: MR imaging for diagnosis","volume":"229","author":"Farres","year":"2003","journal-title":"Radiology"},{"key":"10.1002\/phy2.202-BIB0010|phy2202-cit-0010","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1074\/jbc.M109440200","article-title":"Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2","volume":"277","author":"Fujino","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1002\/phy2.202-BIB0011|phy2202-cit-0011","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1124\/jpet.104.076877","article-title":"Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity","volume":"312","author":"Gierse","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1002\/phy2.202-BIB0012|phy2202-cit-0012","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1172\/JCI117620","article-title":"Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction","volume":"94","author":"Harris","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1002\/phy2.202-BIB0013|phy2202-cit-0013","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/ki.1977.102","article-title":"Chronic renal lesions following long-term treatment with lithium","volume":"12","author":"Hestbech","year":"1977","journal-title":"Kidney Int."},{"key":"10.1002\/phy2.202-BIB0014|phy2202-cit-0014","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1038\/ki.1997.449","article-title":"Differential regulation of renal cyclooxygenase mRNA by dietary salt intake","volume":"52","author":"Jensen","year":"1997","journal-title":"Kidney Int."},{"key":"10.1002\/phy2.202-BIB0015|phy2202-cit-0015","doi-asserted-by":"crossref","first-page":"F1001","DOI":"10.1152\/ajprenal.2001.280.6.F1001","article-title":"Localization of prostaglandin E(2) EP2 and EP4 receptors in the rat kidney","volume":"280","author":"Jensen","year":"2001","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1002\/phy2.202-BIB0016|phy2202-cit-0016","doi-asserted-by":"crossref","first-page":"F1689","DOI":"10.1152\/ajprenal.00117.2009","article-title":"Mice lacking mPGES-1 are resistant to lithium-induced polyuria","volume":"297","author":"Jia","year":"2009","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1002\/phy2.202-BIB0017|phy2202-cit-0017","doi-asserted-by":"crossref","first-page":"F702","DOI":"10.1152\/ajprenal.00366.2007","article-title":"Treating lithium-induced nephrogenic diabetes insipidus with a COX-2 inhibitor improves polyuria via upregulation of AQP2 and NKCC2","volume":"294","author":"Kim","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1002\/phy2.202-BIB0018|phy2202-cit-0018","doi-asserted-by":"crossref","first-page":"F455","DOI":"10.1152\/ajprenal.00144.2011","article-title":"Tissue injury after lithium treatment in human and rat postnatal kidney involves glycogen synthase kinase 3beta-positive epithelium","volume":"302","author":"Kjaersgaard","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1002\/phy2.202-BIB0019|phy2202-cit-0019","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1073\/pnas.93.16.8455","article-title":"A molecular mechanism for the effect of lithium on development","volume":"93","author":"Klein","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1002\/phy2.202-BIB0020|phy2202-cit-0020","doi-asserted-by":"crossref","first-page":"C131","DOI":"10.1152\/ajpcell.00197.2011","article-title":"Lithium reduces aquaporin-2 transcription independent of prostaglandins","volume":"302","author":"Kortenoeven","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1002\/phy2.202-BIB0021|phy2202-cit-0021","doi-asserted-by":"crossref","first-page":"F1053","DOI":"10.1152\/ajprenal.00114.2004","article-title":"Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus","volume":"288","author":"Kotnik","year":"2005","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1002\/phy2.202-BIB0022|phy2202-cit-0022","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3109\/08860229709026274","article-title":"Emergency treatment of lithium-induced diabetes insipidus with nonsteroidal anti-inflammatory drugs","volume":"19","author":"Lam","year":"1997","journal-title":"Ren. Fail."},{"key":"10.1002\/phy2.202-BIB0023|phy2202-cit-0023","doi-asserted-by":"crossref","first-page":"37871","DOI":"10.1074\/jbc.M205627200","article-title":"Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome","volume":"277","author":"Lorenz","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1002\/phy2.202-BIB0024|phy2202-cit-0024","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1046\/j.1523-1755.2001.00466.x","article-title":"Furosemide stimulates macula densa cyclooxygenase-2 expression in rats","volume":"59","author":"Mann","year":"2001","journal-title":"Kidney Int."},{"key":"10.1002\/phy2.202-BIB0025|phy2202-cit-0025","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1172\/JCI117863","article-title":"Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla","volume":"95","author":"Marples","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1002\/phy2.202-BIB0026|phy2202-cit-0026","doi-asserted-by":"crossref","first-page":"F322","DOI":"10.1152\/ajprenal.00061.2005","article-title":"COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction","volume":"289","author":"Norregaard","year":"2005","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1002\/phy2.202-BIB0027|phy2202-cit-0027","doi-asserted-by":"crossref","first-page":"F1322","DOI":"10.1152\/ajprenal.00394.2006","article-title":"COX-2 activity transiently contributes to increased water and NaCl excretion in the polyuric phase after release of ureteral obstruction","volume":"292","author":"Norregaard","year":"2007","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1002\/phy2.202-BIB0028|phy2202-cit-0028","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1600-0773.1988.tb00920.x","article-title":"Lithium-induced morphological changes in the rat kidney at different levels of urine flow","volume":"63","author":"Ottosen","year":"1988","journal-title":"Pharmacol. Toxicol."},{"key":"10.1002\/phy2.202-BIB0029|phy2202-cit-0029","doi-asserted-by":"crossref","first-page":"F642","DOI":"10.1152\/ajprenal.00287.2004","article-title":"Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria","volume":"288","author":"Rao","year":"2005","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1002\/phy2.202-BIB0030|phy2202-cit-0030","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/S0960-9822(02)70790-2","article-title":"Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells","volume":"6","author":"Stambolic","year":"1996","journal-title":"Curr. Biol."},{"key":"10.1002\/phy2.202-BIB0031|phy2202-cit-0031","doi-asserted-by":"crossref","first-page":"R1179","DOI":"10.1152\/ajpregu.00340.2002","article-title":"Cyclooxygenase-2 contributes to elevated renin in the early postnatal period in rats","volume":"284","author":"Stubbe","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1002\/phy2.202-BIB0032|phy2202-cit-0032","doi-asserted-by":"crossref","first-page":"F780","DOI":"10.1152\/ajprenal.00193.2007","article-title":"Postnatal adrenalectomy impairs urinary concentrating ability by increased COX-2 and leads to renal medullary injury","volume":"293","author":"Stubbe","year":"2007","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1002\/phy2.202-BIB0033|phy2202-cit-0033","doi-asserted-by":"crossref","first-page":"R863","DOI":"10.1152\/ajpregu.1988.254.6.R863","article-title":"Involvement of prostaglandin E2, cAMP, and vasopressin in lithium-induced polyuria","volume":"254","author":"Sugawara","year":"1988","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"Pt 1","key":"10.1002\/phy2.202-BIB0034|phy2202-cit-0034","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/bj2960015","article-title":"Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling","volume":"296","author":"Sutherland","year":"1993","journal-title":"Biochem. J."},{"key":"10.1002\/phy2.202-BIB0035|phy2202-cit-0035","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.1073\/pnas.090091297","article-title":"Uncompensated polyuria in a mouse model of Bartter's syndrome","volume":"97","author":"Takahashi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1002\/phy2.202-BIB0036|phy2202-cit-0036","first-page":"F481","article-title":"Regulation of cyclooxygenase expression in the kidney by dietary salt intake","volume":"274","author":"Yang","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1002\/phy2.202-BIB0037|phy2202-cit-0037","doi-asserted-by":"crossref","first-page":"F465","DOI":"10.1152\/ajprenal.00494.2005","article-title":"Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion","volume":"291","author":"Yang","year":"2006","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1002\/phy2.202-BIB0038|phy2202-cit-0038","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2131\/jts.34.519","article-title":"Severe toxicity and cyclooxygenase (COX)-2 mRNA increase by lithium in the neonatal mouse kidney","volume":"34","author":"Yoshioka","year":"2009","journal-title":"J. Toxicol. Sci."}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fphy2.202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/phy2.202\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T10:30:28Z","timestamp":1517308228000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/phy2.202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"URL":"https:\/\/doi.org\/10.1002\/phy2.202","archive":["Portico"],"relation":{},"ISSN":["2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}