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The Arabidopsis transcription factors <jats:italic>MYB58<\/jats:italic> and <jats:italic>MYB63<\/jats:italic> have been shown to upregulate gene expression of the general phenylpropanoid and monolignol biosynthetic pathways. The overexpression of these genes also results in dwarfism. The vascular integrity, soluble phenolic profiles, cell wall lignin, and transcriptomes associated with these MYB\u2010overexpressing lines were characterized. Plants with high expression of <jats:italic>MYB58<\/jats:italic> and <jats:italic>MYB63<\/jats:italic> had increased ectopic lignin and the xylem vessels were regular and open, suggesting that the stunted growth is not associated with loss of vascular conductivity. <jats:italic>MYB58<\/jats:italic> and <jats:italic>MYB63<\/jats:italic> overexpression lines had characteristic soluble phenolic profiles with large amounts of monolignol glucosides and sinapoyl esters, but decreased flavonoids. Because loss of function <jats:italic>lac4 lac17<\/jats:italic> mutants also accumulate monolignol glucosides, we hypothesized that LACCASE overexpression might decrease monolignol glucoside levels in the MYB\u2010overexpressing plant lines. When laccases related to lignification (<jats:italic>LAC4<\/jats:italic> or <jats:italic>LAC17<\/jats:italic>) were co\u2010overexpressed with <jats:italic>MYB63<\/jats:italic> or <jats:italic>MYB58<\/jats:italic>, the dwarf phenotype was rescued. Moreover, the overexpression of either <jats:italic>LAC4<\/jats:italic> or <jats:italic>LAC17<\/jats:italic> led to wild\u2010type monolignol glucoside levels, as well as wild\u2010type lignin levels in the rescued plants. Transcriptomes of the rescued double <jats:italic>MYB63\u2010OX\/LAC17\u2010OX<\/jats:italic> overexpression lines showed elevated, but attenuated, expression of the <jats:italic>MYB63<\/jats:italic> gene itself and the direct transcriptional targets of MYB63. Contrasting the dwarfism from overabundant monolignol production with dwarfism from lignin mutants provides insight into some of the proposed mechanisms of lignin modification\u2010induced dwarfism.<\/jats:p>","DOI":"10.1002\/pld3.265","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T08:41:50Z","timestamp":1601282510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Dwarfism of high\u2010monolignol Arabidopsis plants is rescued by ectopic LACCASE overexpression"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6767-2707","authenticated-orcid":false,"given":"Mendel L.","family":"Perkins","sequence":"first","affiliation":[{"name":"Department of Botany University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Schuetz","sequence":"additional","affiliation":[{"name":"Department of Botany University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faride","family":"Unda","sequence":"additional","affiliation":[{"name":"Department of Wood Science University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Botany University of British Columbia Vancouver Canada"},{"name":"Department of Energy's Great Lakes Bioenergy Research Center Department of Biochemistry University of Wisconsin\u2010Madison Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0639-5643","authenticated-orcid":false,"given":"Richard","family":"Sibout","sequence":"additional","affiliation":[{"name":"Department of Botany University of British Columbia Vancouver Canada"},{"name":"UR1268 BIA (Biopolym\u00e8res Interactions Assemblages) INRA Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7557-8283","authenticated-orcid":false,"given":"Natalie J.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Botany University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren C. 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