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In this study, the leaf structure as observed by light and electron microscopy, the phytochemical composition of the volatile organic compounds, and the cytotoxic activity of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S.\u2009tomentosum<\/jats:italic>\n                    <\/jats:styled-content>\n                    are presented. The secretory ducts located above and within the phloem and below the xylem part of the vascular bundle represent the first description of the leaf secretory structures of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S.\u2009tomentosum<\/jats:italic>\n                    <\/jats:styled-content>\n                    . The essential oil and hydrosol were extracted from air\u2010dried leaves by Clevenger distillation and analyzed by gas chromatography\u2013mass spectrometry, combined with headspace solid\u2010phase microextraction of volatiles from the hydrosol and fresh plant material. \u03b1\u2010Amorphene, \u03b2\u2010caryophyllene, germacrene D, \u03b2\u2010cadinene, and \u03b1\u2010copaene were the most abundant sesquiterpenes in the essential oil and fresh plant material. Among the monoterpenes, \u03b1\u2010pinene was most abundant in the essential oil, limonene in fresh plant material, and \u03b1\u2010terpineol in the hydrosol. Moderate cytotoxic activity of the methanolic extract of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S.\u2009tomentosum<\/jats:italic>\n                    <\/jats:styled-content>\n                    , with higher inhibition of cell division observed in the human cervical cancer and osteosarcoma cell lines, and weaker activity in the healthy retinal pigmented epithelial and colon cancer cell lines, was detected using the MTS\u2010based assay. With these results, we aim to highlight the potential of endemic plants, emphasizing the importance of studying species such as\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S.\u2009tomentosum<\/jats:italic>\n                    <\/jats:styled-content>\n                    and their contributions to biodiversity and human health as sources of bioactive compounds.\n                  <\/jats:p>","DOI":"10.1002\/pld3.70119","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T04:56:33Z","timestamp":1763614593000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Leaf Anatomy, Volatile Metabolite Profile, and Cytotoxic Activity of the Endemic\n                    <scp>\n                      <i>Seseli\u2009tomentosum<\/i>\n                    <\/scp>\n                    Vis.: Insights Into Species\u2010Specific Adaptations"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8372-0622","authenticated-orcid":false,"given":"Elma","family":"Vuko","sequence":"first","affiliation":[{"name":"Faculty of Science University of Split  Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanja","family":"Radman","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Technology University of Split  Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5023-1016","authenticated-orcid":false,"given":"Juraj","family":"Kamenjarin","sequence":"additional","affiliation":[{"name":"Faculty of Science University of Split  Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3868-0828","authenticated-orcid":false,"given":"Ivana","family":"Bo\u010dina","sequence":"additional","affiliation":[{"name":"Faculty of Science University of Split  Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ema","family":"Topalovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Science University of Split  Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6897-2445","authenticated-orcid":false,"given":"\u017deljana","family":"Fredotovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Science University of Split  Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/anbo.1997.0550"},{"issue":"3","key":"e_1_2_9_3_1","first-page":"241","article-title":"Cumarinas en Especies del Genero Seseli (Fam. 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