{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:25:38Z","timestamp":1783412738322,"version":"3.54.6"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pregnancy"],"published-print":{"date-parts":[[2025,5]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n Little is known about outcomes of subsequent gestation following a pregnancy complicated by previable\/periviable preterm prelabor rupture of membrane (pPPROM). The objective of this study is to describe outcomes in subsequent gestation after a pregnancy complicated by pPPROM.<\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n We performed a retrospective cohort study of the subsequent pregnancy for patients with a history of pPPROM (rupture of membranes\u00a0<\u00a023\u00a0weeks) in the previous gestation of our institution from 2013 to 2022. All pregnancies were dated by ultrasound prior to pPPROM in the initial cohort. No anomalous fetuses were seen in this cohort. Subsequent pregnancies continuing beyond 13 weeks and 6 days were included in the analysis. Our primary outcome was gestational age (GA) at delivery in the subsequent pregnancy. Secondary outcomes included recurrent preterm birth (PTB), recurrent PPROM, and recurrent pPPROM. Secondary analysis was performed comparing patients delivering preterm versus term in subsequent pregnancy, and excluding patients missing delivery data or with loss\u00a0<\u00a014 weeks.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 100 patients with pPPROM, 42 patients (42%) had a subsequent pregnancy. Out of 42, 36 (85.7%) reached second trimester, 5 (11.9%) had first trimester loss, including one ectopic pregnancy of four spontaneous abortions at\u00a0<\u00a012\u00a0weeks, and one was lost to follow\u2010up. Median GA at delivery in the subsequent pregnancy (\n n<\/jats:italic>\n \u00a0=\u00a036) was 37.4 weeks (IQR 35.6, 38.9 weeks). Out of 36 patients, 10 patients (27.8%) had recurrent PTB, of whom 4 (11.1%) had recurrent PPROM and 2 (5.6%) had recurrent previable PPROM. One patient had periviable preterm labor. The median GA delivery of patients delivering preterm (\n n<\/jats:italic>\n \u00a0=\u00a010) was 30.4 weeks (IQR 21.4, 34.3 weeks). Demographics, GA at pPPROM in the first pregnancy, and use of 17\u2010P and\/or cerclage did not differ between those who did and did not deliver preterm in the subsequent pregnancy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In patients with prior pPPROM with subsequent pregnancy continuing beyond the first trimester, more than two\u2010thirds delivered at term in the subsequent pregnancy. However, recurrent previable PPROM occurred in 5.6% of patients. No clear risk factors for recurrent PTB (beyond PTB history) were identified in this cohort.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/pmf2.70008","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T23:21:11Z","timestamp":1744327271000},"source":"Crossref","is-referenced-by-count":1,"title":["Outcomes in the immediate subsequent gestation following a pregnancy complicated by previable preterm prelabor rupture of membranes"],"prefix":"10.1002","volume":"1","author":[{"given":"Jessie Y.","family":"Li\u2010Barton","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Okunbor","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Brown University Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan","family":"Sugrue","sequence":"additional","affiliation":[{"name":"The Coombe University Hospital University College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarahn","family":"Wheeler","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Grace","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Dotters\u2010Katz","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004142"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(03)00073-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.15239"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.08.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.12.010"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90481-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.115"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1353389"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001682"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-015402"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2017.08.010"},{"issue":"3","key":"e_1_2_8_13_1","article-title":"Racial Disparities in Prematurity Persist among Women of High Socioeconomic Status","volume":"2","author":"Johnson J. D.","year":"2020","journal-title":"American Journal of Obstetrics & Gynecology Maternal\u2010Fetal Medicine"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.12.034"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2028-7633"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2024.07.016"}],"container-title":["Pregnancy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmf2.70008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T07:28:45Z","timestamp":1764055725000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pmf2.70008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,10]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/pmf2.70008"],"URL":"https:\/\/doi.org\/10.1002\/pmf2.70008","archive":["Portico"],"relation":{},"ISSN":["2997-9684","2997-9684"],"issn-type":[{"value":"2997-9684","type":"print"},{"value":"2997-9684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,10]]},"article-number":"e70008"}}