{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T12:45:39Z","timestamp":1765111539051,"version":"3.46.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pregnancy"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pregnancies with sickle\u2010cell disease are at high risk of maternal, obstetrical, and fetal complications, for which prostaglandins are often indicated to induce labor or to treat postpartum hemorrhage. There is concern that prostaglandin use may increase the risk of vaso\u2010occlusion, but to date no clinical study has yet assessed this risk. Our objective was to assess the safety of prostaglandins during delivery and postpartum in women with sickle\u2010cell disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A retrospective multicenter cohort study in 10 tertiary university\u2010affiliated centers in France, including all women with sickle\u2010cell disease (S\/S, S\/C, or S\/\u03b2\u2010thalassemia) delivering in the centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared pregnancies with and without exposure to prostaglandins, overall and specifically according to whether prostaglandins were used for labor induction or for postpartum hemorrhage. The main outcome was the occurrence of vaso\u2010occlusive crisis and\/or thromboembolism, within 7 days after delivery. Secondary outcomes were vaso\u2010occlusive crises requiring intravenous morphine and\/or intensive care admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Prostaglandins were used in 114\/411 pregnancies (27.7%). In 106\/411 (25.8%), they were used to induce labor, with Prostaglandin E2 (dinoprostone gel or pessary) for 95 patients and misoprostol for 11 patients. The incidence of postpartum hemorrhage was 60\/411 (14.6%), and 11 cases required second\u2010line therapy with prostaglandins; sulprostone was used as per French practice guidelines. The incidence of vaso\u2010occlusive crises and\/or venous thromboembolism in the postpartum did not differ between patients exposed and not exposed to prostaglandins (14\/114 (12.2%) vs. 34\/293 (11.6%), respectively;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.87), nor did the incidence of severe vaso\u2010occlusive crises requiring morphine and\/or intensive care unit hospitalization (7.0% vs. 7.8%, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.78). Among patients undergoing labor induction, acute complications occurred in 12\/106 (11.6%) exposed to prostaglandins versus 6\/77 (7.6%) unexposed (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.46). Among patients with postpartum hemorrhage, rates were respectively 2\/11 (18.2%) versus 9\/49 (18.4%;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.99).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of prostaglandins in patients with sickle\u2010cell disease for labor induction or for postpartum hemorrhage appeared safe, within the limitations of a retrospective study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pmf2.70014","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T09:09:54Z","timestamp":1755767394000},"source":"Crossref","is-referenced-by-count":0,"title":["Safety of prostaglandins in the peripartum period in case of sickle\u2010cell disease: A multicenter cohort study"],"prefix":"10.1002","volume":"1","author":[{"given":"Mayi","family":"Gnofam","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Louis Mourier, and FHU PREMA  Colombes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Sibiude","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Louis Mourier, and FHU PREMA  Colombes France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Inserm IAME  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Affo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Louis Mourier  Colombes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Galacteros","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Assistance Publique\u2010H\u00f4pitaux de Paris Red Cell Genetic Disease Unit GHU Henri Mondor U\u2010PEC, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Lecarpentier","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Centre Hospitalier Intercommunal Cr\u00e9teil Universit\u00e9 Paris\u2010Est Cr\u00e9teil, IMRB INSERM U955  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Louis Mourier, and FHU PREMA  Colombes France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marine","family":"Driessen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Necker AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Graesslin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology H\u00f4pital Maison Blanche  Reims France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gylna","family":"Loko","sequence":"additional","affiliation":[{"name":"Sickle Cell Disease Reference Center H\u00f4pital La Meynard  Martinique Fort\u2010de\u2010France France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Cannas","sequence":"additional","affiliation":[{"name":"Sickle Cell Disease Reference Center H\u00f4pital E. Herriot HCL  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Bounan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology H\u00f4pital Delafontaine  Saint Denis France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herv\u00e9","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Bic\u00eatre  Le Kremlin Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Debarge","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Centre Hospitalier Universitaire de Lille  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Makowski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Centre Hospitalier Universitaire Grenoble Alpes  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Mandelbrot","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Louis Mourier, and FHU PREMA  Colombes France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Inserm IAME  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Drepagest Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510865"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00310-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13270"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.10.031"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011301"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020597"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h217"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2015.12.012"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197204062861419"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(00)00342-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/19.1.23"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830020205"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.6615.1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/677363"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-014-0293-6"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.7.2551"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-884346"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14823"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007089"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2022000378"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17667"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2015.09.016"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-638288"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830430431"},{"key":"e_1_2_6_27_1","unstructured":"Epop\u00e9 I..2022.Enqu\u00eate Nationale P\u00e9rinatale 2021: Sant\u00e9 Publique France.https:\/\/www.santepubliquefrance.fr\/presse\/2022\/enquete\u2010nationale\u2010perinatale\u2010resultats\u2010de\u2010l\u2010edition\u20102021."},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2013.04.006"}],"container-title":["Pregnancy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmf2.70014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T12:41:12Z","timestamp":1765111272000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pmf2.70014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/pmf2.70014"],"URL":"https:\/\/doi.org\/10.1002\/pmf2.70014","archive":["Portico"],"relation":{},"ISSN":["2997-9684","2997-9684"],"issn-type":[{"type":"print","value":"2997-9684"},{"type":"electronic","value":"2997-9684"}],"subject":[],"published":{"date-parts":[[2025,8,21]]},"article-number":"e70014"}}