{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T23:33:10Z","timestamp":1786491190297,"version":"build-2736575974"},"reference-count":76,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U01HL145358"],"award-info":[{"award-number":["U01HL145358"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG085475"],"award-info":[{"award-number":["R01AG085475"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pregnancy"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Hypertensive disorders of pregnancy (HDP) are associated with a long\u2010term risk of maternal cognitive decline. Limited data exist regarding maternal brain structure in midlife after HDP. We examined the association between prior HDP and neuroimaging markers associated with microvascular brain injury, detected on high\u2010resolution brain MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a pilot study embedded within the nuMoM2b Heart Health Study, a multicenter prospective cohort of nulliparous US individuals recruited between 2010 and 2013 in the first trimester of pregnancy. Participants with no history of HDP, preterm birth, small\u2010for\u2010gestational age infant, or stillbirth in any pregnancy, and participants with HDP in the index or any subsequent pregnancy were invited to undergo brain MRI at two study sites between December 21, 2021 and September 30, 2023, using a standardized protocol on identical scanners. Imaging outcomes of interest included white matter hyperintensity (WMH) volume, regional cerebral blood flow (CBF), fractional anisotropy (FA), radial diffusivity (RD), regional grey matter volume (GMV), and cortical thinning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 81 participants (mean age 39 years; 27% White, 9% non\u2010Hispanic Black, 52% Hispanic, 10% Asian) had brain MRI, of whom 27 (33%) had a history of HDP. The median time from index delivery to MRI was 11 years. Participants with HDP had lower CBF in the left medial orbitofrontal, left inferior temporal, and right superior temporal lobes (Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      = 0.3, cluster\u2010wise corrected\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0002 for all subregions); lower FA in the left superior frontal lobe, right lateral occipital lobe, and right precuneus (\n                      <jats:italic>d<\/jats:italic>\n                      = 0.2\u20130.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2264 0.01 for all regions); and higher RD in the bilateral medial orbitofrontal lobes (\n                      <jats:italic>d<\/jats:italic>\n                      = 0.2\u20130.3,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Cortical thickness, regional GMV, and total WMH volume did not differ between groups. A subgroup analysis including only participants with preeclampsia in the exposed group showed similar results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Midlife individuals who experienced HDP had lower regional CBF and reduced white matter microstructural integrity, compared with those with no adverse pregnancy outcomes. Our results suggest that HDP are associated with long\u2010term impairment of white matter structure and cerebrovascular function, potentially suggesting a mechanism underlying the association of HDP with risk of cognitive decline, and requiring further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pmf2.70020","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T12:35:28Z","timestamp":1745498128000},"source":"Crossref","is-referenced-by-count":7,"title":["Hypertensive disorders of pregnancy and neuroimaging markers of dementia risk: A pilot study"],"prefix":"10.1002","volume":"1","author":[{"given":"Mohamad J.","family":"Alshikho","sequence":"first","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University Vagelos College of Physicians and Surgeons  New York New York 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V.","family":"Lippert","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University Vagelos College of Physicians and Surgeons  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejania","family":"Cotton\u2010Samuel","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University Vagelos College of Physicians and Surgeons  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheica","family":"Cedano","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Columbia University Vagelos College of Physicians and Surgeons  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie De La Cruz","family":"Vasquez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology 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