{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:33:00Z","timestamp":1754159580650,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["#1435\/20"],"award-info":[{"award-number":["#1435\/20"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pregnancy"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>It is estimated that 30%\u201350% of spontaneous preterm deliveries (PTDs) are caused by infectious states. Acute\u2010phase responders (APRs) accompany chronic as well as acute inflammatory states. In addition, hyperlipidemia is considered as a precursor of inflammation and oxidative stress. This study aimed to examine the associations between maternal serum levels of lipids and APRs in the 1st trimester of pregnancy and pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cohort study was conducted among multipara individuals with singleton pregnancies. Recruitment took place between 11 and 13 gestational weeks. The exposures were serum levels of the following APRs: C\u2010 reactive protein, albumin, triglyceride, total cholesterol, low density lipoprotein calculated (LDL\u2010c), and high density lipoprotein. The outcomes were gestational diabetes mellitus, preeclampsia, gestational age at delivery, PTD (&lt;\u00a037 gestational weeks + 0 days), low birthweight, and macrosomia. Participants with the lowest or highest levels for each APR were identified based on clinical cut points. Multivariable analyses were performed to evaluate the independent association between the APRs and the studied outcomes, including linear models for gestational age at delivery or birthweight, and logistic models for PTD and other outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>A total of 201 participants were included in the study. Mean birthweight was higher among individuals with high total cholesterol (3392.710\u00a0\u00b1\u00a0426 g vs. 3220.782\u00a0\u00b1\u00a0448 g, <jats:italic>p<\/jats:italic> value\u00a0=\u00a00.01). Similarly, mean birthweight was higher among individuals with high LDL\u2010c (3414.520\u00a0\u00b1\u00a0407 g vs. 3237.324\u00a0\u00b1\u00a0453 g, <jats:italic>p<\/jats:italic> value\u00a0=\u00a00.018). In multivariable linear models for the association between total cholesterol or LDL\u2010c and birthweight, which adjusted for newborn sex, gestational age at delivery, gestational diabetes mellitus or pregestational diabetes mellitus, and maternal body mass index (BMI), an increase in one unit of total cholesterol was significantly related with higher birthweight (2.796 g per unit, 95% CI\u00a0=\u00a00.682\u20133.956), and an increase in one unit of LDL\u2010c was significantly related with higher birthweight (2.463 g per unit, 95% CI\u00a0=\u00a00.152\u20134.773). No associations were found between early pregnancy APRs and PTD, gestational age at delivery, and the other outcomes of interest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher birthweight was found among individuals with high early pregnancy total cholesterol and LDL\u2010c levels, even after controlling for maternal BMI. Early monitoring of maternal lipid profile may serve as a useful predictor of excessive fetal growth, providing a potential tool for identifying pregnancies and individuals at higher risk for this complication, and which could benefit from closer observation. Levels of APRs were not associated with other pregnancy outcomes of interest.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pmf2.70049","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T09:13:32Z","timestamp":1749806012000},"source":"Crossref","is-referenced-by-count":0,"title":["Early pregnancy maternal lipid profile, acute phase responders, and the association with preterm delivery and selected pregnancy outcomes"],"prefix":"10.1002","volume":"1","author":[{"given":"Ayal","family":"Haimov","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences Joyce &amp; Irving Goldman Medical School at Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Sheiner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Soroka University Medical Center Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maayan Hagbi","family":"Bal","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Rosenbaum","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Joyce &amp; Irving Goldman Medical School at Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doron","family":"Bergman","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Joyce &amp; Irving Goldman Medical School at Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ifat Baram","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Joyce &amp; Irving Goldman Medical School at Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noam","family":"Tomasis","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Joyce &amp; Irving Goldman Medical School at Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Wainstock","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2206346"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400607"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.03.016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/xJAHA.112.000497"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-2115(95)02203-J"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.02.022"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh179"},{"issue":"7","key":"e_1_2_8_9_1","first-page":"1517","article-title":"Can We Predict Preterm Delivery Based on the Previous Pregnancy?","volume":"10","author":"Wainstock T.","year":"2021","journal-title":"Joint Consultative Machinery"},{"issue":"9","key":"e_1_2_8_10_1","article-title":"Cross\u2010Country Individual Participant Analysis of 4.1 Million Singleton Births in 5 Countries with Very High Human Development Index Confirms Known Associations but Provides No Biologic Explanation for 2\/3 of All Preterm Births","volume":"11","author":"Ferrero D. 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