{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T12:40:52Z","timestamp":1776602452573,"version":"3.51.2"},"reference-count":70,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pregnancy"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hypertensive disorder of pregnancy (HDP) is associated with an increased risk for later\u2010life cardiovascular disease (CVD). Whether the HDP pregnancy itself confers risk toward CVD later in life is suggested in several epidemiologic studies. Given this connection and that the HDP exposure itself may play a role, understanding whether markers associated with cardiovascular risk vary based on HDP history in the years following pregnancy may assist with risk stratification and development of targeted interventions. We measured 77 proteins (CVD\u2010associated and inflammatory markers) in\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a022 individuals with a history of HDP and\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a042 matched controls with no HDP history at a median of 4 years after pregnancy. Several CVD\u2010associated proteins (fibrinogen, fetuin\u2010A, L\u2010selectin, and alpha\u20101\u2010acid glycoprotein) were significantly elevated, by orders of magnitude, in individuals with a history of HDP compared to normotensive pregnancies (all\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001). In multivariable linear regression models controlling for age, body mass index, chronic hypertension, and diabetes, a history of HDP remained associated with higher levels of CVD\u2010associated proteins (all\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001). We clustered samples based on global patterns of CVD protein expression and found a significant difference in CVD protein expression patterns between post\u2010Normal and post\u2010HDP samples. Conversely, differences in circulating inflammatory markers were largely insignificant or more subtle than those observed with the CVD\u2010associated proteins. Identification of biomarkers associated with CVD in the intervening years after HDP but before evident CVD is critical to understanding post\u2010HDP cardiovascular risk to provide insight for the development of therapeutic interventions that mitigate CVD event risk in this high\u2010risk population.\n                  <\/jats:p>","DOI":"10.1002\/pmf2.70064","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T20:06:31Z","timestamp":1757707591000},"source":"Crossref","is-referenced-by-count":2,"title":["Higher Levels of Cardiovascular Biomarkers Following Hypertensive Compared to Normotensive Pregnancy"],"prefix":"10.1002","volume":"1","author":[{"given":"Austin M.","family":"Gabel","sequence":"first","affiliation":[{"name":"Medical Scientist Training Program University of Washington  Seattle Washington 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A.","family":"McCartney","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj","family":"Shree","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"issue":"8","key":"e_1_2_8_2_1","first-page":"e254","article-title":"Heart Disease and Stroke Statistics\u20142021 Update","volume":"143","author":"Virani Salim 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