{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:26:32Z","timestamp":1789503992875,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pregnancy"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Iron\u2010deficiency anemia (IDA) affects over one\u2010third of pregnant patients globally, contributing to severe maternal morbidity and adverse neonatal outcomes. Oral iron supplementation, while cost\u2010effective, is limited by poor absorption, significant gastrointestinal side effects, and poor adherence. The use of intravenous (IV) iron addresses many of these concerns, including eliminating GI side effects and the need for daily therapy. However, administration of IV iron in pregnant patients is typically restricted to specialized infusion centers or hospitals due to concerns about acute side effects, cost, resource utilization, the need for fetal heart rate monitoring, and extended infusion times.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This descriptive study evaluated the implementation, safety, and feasibility of outpatient IV iron infusions for pregnant patients with IDA, with maternal hemoglobin response and outcomes reported as secondary findings. Patients received a single or series of doses of IV iron spaced weekly, with hemoglobin levels monitored before and after treatment. No fetal heart tracing was performed. Antepartum patients treated with IV iron at our outpatient obstetric clinic from 2017 to 2024 were identified retrospectively, and their charts were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 417 pregnant patients received IV iron (87.3% iron sucrose; 12.7% Ferric Carboxymaltose); 65.9% received \u2265600\u00a0mg total dose (2\u20133 dose protocol), while 34.1% received lower cumulative doses (1\u20132 infusions). Therapy was well\u2010tolerated with no anaphylactic reactions reported. Side effects were experienced in only 11.5% of patients and were relatively minor, with dizziness (6.2%), headache (1.9%), and hypotension (1.7%) being the most common. Adverse maternal outcomes (PPH, ICU admission, blood transfusions, and re\u2010admissions) were low, particularly in patients who received the last infusion more than 10 days before delivery. Neonatal outcomes included a 7.4% NICU admission rate and a 3.5% rate of infants weighing less than 2500 g. Mean hemoglobin increased by 1.5\u00a0g\/dL, consistent with prior studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that IV iron therapy can be safely given in obstetrical clinics without significant maternal or fetal safety concerns. This obviates the need for more resource\u2010intensive and costly settings such as infusion or hospital\u2010based centers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pmf2.70067","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T19:35:16Z","timestamp":1755891316000},"source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness and Safety of Intravenous Iron Therapy in Outpatient Obstetrical Clinic for Treatment of Iron\u2010Deficiency Anemia During Pregnancy"],"prefix":"10.1002","volume":"1","author":[{"given":"Ellen M.","family":"Murrin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal\u2010Fetal Medicine Inova Fairfax Hospital Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia S.","family":"LeBeau","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal\u2010Fetal Medicine Inova Fairfax Hospital Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal\u2010Fetal Medicine Inova Fairfax Hospital Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Kassab","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal\u2010Fetal Medicine Inova Fairfax Hospital Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyton","family":"Kalan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal\u2010Fetal Medicine Inova Fairfax Hospital Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Costanzo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal\u2010Fetal Medicine Inova Fairfax Hospital Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal\u2010Fetal Medicine Inova Fairfax Hospital Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George L.","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal\u2010Fetal Medicine Inova Fairfax Hospital Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George R.","family":"Saade","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics &amp; Gynecology Eastern Virginia Medical School Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio F.","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal\u2010Fetal Medicine Inova Fairfax Hospital Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Anaemia Fact Sheets.World Health Organization 2023."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2015.2.10289"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.29151"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.53738\/REVMED.2007.3.105.0874"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000480743"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.12.016"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2019000034"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000005143"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000532929.35226.2a"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1668555"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12417"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-14-115"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/heapol\/czaa110"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-019-2200-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27220"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/630519"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.16075"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2025.01.037"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13561-023-00474-3"},{"key":"e_1_2_6_21_1","article-title":"Effects of Maternal Anemia Affecting Fetal Outcomes: A Narrative Review","volume":"16","author":"Kharate M. 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