{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T12:46:35Z","timestamp":1765111595612,"version":"3.46.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pregnancy"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Fluid abnormalities should resolve after fetoscopic laser surgery (FLS) for Twin to Twin Transfusion Syndrome (TTTS), but polyhydramnios occasionally persists. We sought to compare patients with persistent polyhydramnios (PP) to those with resolved polyhydramnios (RP) after FLS for TTTS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Single\u2010center retrospective review of monochorionic twins who underwent FLS for TTTS from June 2014 to January 2024. Patients with RP had resolution of polyhydramnios\u00a0\u2264\u00a014 days after FLS. PP patients had a maximum vertical pocket (MVP) \u2265 8\u00a0cm in the former TTTS recipient\u00a0&gt;\u00a014 days after FLS. Patients with septostomy, global membrane separation, membrane rupture within 2 weeks of laser, early recipient demise \u2264 14 days after FLS, TTTS recurrence, or undergoing repeat FLS were excluded. Pretreatment characteristics and birth outcomes were compared between PP and RP groups via Pearson or Fischer's exact chi\u2010squared and Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test. We chose gestational age (GA) at delivery as our primary outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 317 out of 336 (94.3%) patients had RP after FLS, and 19 (5.7%) patients had PP. PP recipients had higher pre\u2010FLS MVP (12.5\u00a0vs. 10.0\u00a0cm,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003), higher amnioreduction volumes (2000\u00a0vs. 1500\u00a0mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.030), and higher postoperative day 1 MVPs (7.0\u00a0vs. 6.0\u00a0cm,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009). There was a trend toward a higher rate of preoperative recipient pyelectasis in patients with PP (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.069). Average time to resolution of polyhydramnios was 2 days in RP group versus 28 days in the PP group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Polyhydramnios resolved in 17\/18 (94.4%) of PP cases with available outcomes. GAs at delivery, birth survival, and birthweight discordance were not different between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PP occurred in 5.7% of patients after FLS for TTTS. Resolution of PP occurred in 94.4% of PP patients in a median of 28 days and was not associated with adverse obstetric outcomes. The trend of increased incidence of recipient pyelectasis suggests delayed resolution of recipient polyuria as a potential etiology of PP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pmf2.70098","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T12:02:56Z","timestamp":1758715376000},"source":"Crossref","is-referenced-by-count":0,"title":["Postlaser persistent polyhydramnios after resolution of Twin to Twin Transfusion Syndrome"],"prefix":"10.1002","volume":"1","author":[{"given":"Mackenzie","family":"Simon\u2010Collins","sequence":"first","affiliation":[{"name":"Department of Population Family &amp; Reproductive Health Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Shantz","sequence":"additional","affiliation":[{"name":"Center for Fetal Therapy Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachana","family":"Tanksali","sequence":"additional","affiliation":[{"name":"Center for Fetal Therapy Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryn","family":"Day","sequence":"additional","affiliation":[{"name":"Center for Fetal Therapy Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Alan","sequence":"additional","affiliation":[{"name":"Center for Fetal Therapy Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Millard","sequence":"additional","affiliation":[{"name":"Center for Fetal Therapy Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Kush","sequence":"additional","affiliation":[{"name":"Center for Fetal Therapy Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jena","family":"Miller","sequence":"additional","affiliation":[{"name":"Center for Fetal Therapy Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Baschat","sequence":"additional","affiliation":[{"name":"Center for Fetal Therapy Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara","family":"Rosner","sequence":"additional","affiliation":[{"name":"Center for Fetal Therapy Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp\u201020\u2010264"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12492"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.06.081"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa032597"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aog.0000225945.17022.6b"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.27620"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.05.034"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26095"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6246"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2025.2463424"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2010.29.10.1431"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100033\u20101360163"},{"volume-title":"StatPearls","year":"2025","author":"Hwang D. 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