{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:21:01Z","timestamp":1779931261636,"version":"3.53.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pregnancy"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Opioids are commonly prescribed to manage postpartum pain. Yet, 1.7%\u20132.2% of postpartum people develop new persistent use of opioids after receiving a postpartum opioid prescription. Individuals who experience opioid misuse often have mental health comorbidities. A common mental health condition among pregnant individuals is depression. Information about the association between prenatal depression and persistent opioid use postpartum could guide shared decision\u2010making during counseling, but most available studies rely on insurance claims data, which do not capture non\u2010prescribed opioids. In this study, we examined the association between prenatal depression and persistent postpartum opioid use in selected US states.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used data from the 2019 Pregnancy Risk Assessment Monitoring System (PRAMS) Core Questionnaire, Opioid Supplement, and Opioid Call Back Survey from six states (Kentucky, Louisiana, Massachusetts, Missouri, Pennsylvania, and Utah) to examine the association between prenatal depression and persistent postpartum opioid use (defined as postpartum opioid use for 4 weeks or more) in the United States. The survey captured postpartum use of pharmaceutical opioids, including those prescribed to the respondent and those prescribed to another individual. Unadjusted and adjusted logistic regression models were used to assess the association among postpartum individuals. We calculated marginal effects and presented the study results as percentage point differences with 95% CIs. All models used PRAMS survey weights.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1680 individuals were included in the study, corresponding to 154,878 birthing people in the United States. Of these individuals, the prevalence of prenatal depression was 18.2%. Among those with prenatal depression, 12.3% (95% CI: 7.3, 20.1) of individuals had persistent postpartum opioid use compared to 3.3% (95% CI: 2.3, 4.7) among individuals without prenatal depression (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). After adjusting for age group, race\/ethnicity, educational level, cesarean delivery, and preterm birth, prenatal depression was associated with a 6.6\u2010percentage\u2010point (95% CI: 1.9, 11.3) increase in persistent postpartum opioid use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Individuals with depression during pregnancy were more likely to develop persistent postpartum opioid use. Recognizing the relationship between prenatal depression and persistent postpartum opioid use may help tailor postpartum pain management and counseling strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pmf2.70105","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T14:49:50Z","timestamp":1758034190000},"source":"Crossref","is-referenced-by-count":1,"title":["The association between prenatal depression and persistent postpartum pharmaceutical opioid use in six US states"],"prefix":"10.1002","volume":"1","author":[{"given":"Linqing","family":"Zheng","sequence":"first","affiliation":[{"name":"Brown University School of Public Health  Providence Rhode Island USA"},{"name":"University of New England College of Osteopathic Medicine  Biddeford Maine 04005 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily S.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Maternal Fetal Medicine Warren Alpert Medical School of Brown University and Women &amp; Infants Hospital  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria W.","family":"Steenland","sequence":"additional","affiliation":[{"name":"University of Maryland School of Public Health  College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"American College of Obstetricians and Gynecologists.Pharmacologic Stepwise Multimodal Approach for Postpartum Pain Management. Accessed April 18 2024.https:\/\/www.acog.org\/clinical\/clinical\u2010guidance\/clinical\u2010consensus\/articles\/2021\/09\/pharmacologic\u2010stepwise\u2010multimodal\u2010approach\u2010for\u2010postpartum\u2010pain\u2010management."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.7863"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2021.100475"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2023.4523"},{"key":"e_1_2_10_6_1","unstructured":"Depression During Pregnancy. Accessed April 18 2024.https:\/\/www.acog.org\/womens\u2010health\/faqs\/depression\u2010during\u2010pregnancy."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6919a2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000603"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000364"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2006.06.015"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304\u20103959(02)00007\u20106"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.04.042"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2023_448"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2023.101009"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.03.020"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.13028"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/ps.62.10.pss6210_1159"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002093"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002095"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6928a1"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2018.304563"},{"key":"e_1_2_10_22_1","unstructured":"PRAMS Special Projects.PRAMS | CDC. June 21 2023. Accessed April 19 2024.https:\/\/www.cdc.gov\/prams\/special\u2010projects\/index.htm."},{"key":"e_1_2_10_23_1","unstructured":"2019 PRAMS Response Rate Table. April 22 2022. Accessed April 19 2024.https:\/\/www.cdc.gov\/prams\/prams\u2010data\/response\u2010rate\u2010tables\/2019\u2010response\u2010rate\u2010table.html."},{"key":"e_1_2_10_24_1","unstructured":"PRAMS CDC.PRAMS Opioid Supplement Survey2019. Accessed April 19 2024.https:\/\/www.cdc.gov\/prams\/pdf\/questionnaire\/Opioid\u2010Supplement_508.pdf."},{"key":"e_1_2_10_25_1","unstructured":"PRAMS CDC.Opioid Call Back Survey. Accessed April 19 2024.https:\/\/www.cdc.gov\/prams\/pdf\/questionnaire\/Opioid\u2010Call\u2010Questions\u2010508.pdf."},{"key":"e_1_2_10_26_1","unstructured":"PRAMS CDC.Pregnancy Risk Assessment Monitoring System (PRAMS) Phase 8 Core Questionnaire. Accessed April 19 2024.https:\/\/www.cdc.gov\/prams\/pdf\/questionnaire\/Phase\u20108\u2010Core\u2010Questions\u2010508.pdf."},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.10.026"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.03.016"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2023.103644"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr7103a1"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005297"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.whi.2022.08.007"},{"key":"e_1_2_10_33_1","volume-title":"Stata 18 User's Guide","author":"StataCorp","year":"2023"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/1475\u20106773.14337"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010018\u20100117\u20102"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127\u2010022\u201002349\u20100"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000005649"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2020.8862"},{"key":"e_1_2_10_39_1","unstructured":"CDC.2025. \u201cPregnancy\u2010Related Deaths: Data From Maternal Mortality Review Committees in 38 U.S. States 2020.\u201dMaternal Mortality Prevention. Accessed August 2 2025.https:\/\/www.cdc.gov\/maternal\u2010mortality\/php\/data\u2010research\/mmrc\/index.html."}],"container-title":["Pregnancy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmf2.70105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T12:40:32Z","timestamp":1765111232000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pmf2.70105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/pmf2.70105"],"URL":"https:\/\/doi.org\/10.1002\/pmf2.70105","archive":["Portico"],"relation":{},"ISSN":["2997-9684","2997-9684"],"issn-type":[{"value":"2997-9684","type":"print"},{"value":"2997-9684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"article-number":"e70105"}}