{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:31:46Z","timestamp":1782837106666,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD112930"],"award-info":[{"award-number":["R01HD112930"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pregnancy"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the association between mood disorders and peripartum cardiomyopathy (PPCM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrospective cohort study utilizing the National Inpatient Sample from the Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality of pregnant and postpartum patients from 2017 to 2019. Patients were separated into two groups based on ICD\u201010 coding for the presence or absence of mood disorder (depression, bipolar depression, anxiety, or other mood diagnosis). The primary outcome was diagnosis of PPCM. Secondary outcomes included a composite of adverse cardiac events and maternal death. Groups were compared via\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests, chi\u2010squared analysis, and logistic regression that included all variables that differed between groups with\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over 2.2 million subjects were analyzed and approximately 168,000 (7.3%) had an ICD\u201010 diagnosis of mood disorder. Those with mood disorders were more likely to be non\u2010Hispanic white, obese, tobacco users, publicly insured, have comorbidities, and deliver at a large, private, non\u2010profit hospital (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). They were delivered at an earlier gestational age and were also more likely to undergo cesarean (37.0\u00a0\u00b1\u00a04.6\u00a0vs. 37.8\u00a0\u00b1\u00a03.7\u00a0weeks and 35.7%\u00a0vs. 31.8%, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The primary outcome of PPCM was identified twice as often in those with mood disorder (0.12%\u00a0vs. 0.06%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Composite cardiac events, consisting of incidence of acute myocardial infarction, cardiac arrest, cardioversion, cardiac failure, and pulmonary edema, were more frequent among patients with mood disorders (0.35%\u00a0vs. 0.14%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). After controlling for confounders, PPCM remained independently associated with diagnosis of mood disorders (aOR 1.37, 95%CI 1.04\u20131.81) as did the composite of adverse cardiac events (aOR 1.58, 95% CI 1.38\u20131.82).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Mood disorders in pregnancy and postpartum are associated with increased rates of PPCM and other cardiac events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pmf2.70106","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T18:06:34Z","timestamp":1758218794000},"source":"Crossref","is-referenced-by-count":1,"title":["Mood disorders and peripartum cardiomyopathy"],"prefix":"10.1002","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0493-4454","authenticated-orcid":false,"given":"Blake","family":"Neuburg","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Harris","sequence":"additional","affiliation":[{"name":"Institute for Health and Equity Division of Epidemiology and Social Sciences Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Palatnik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Medical College of Wisconsin  Milwaukee Wisconsin USA"},{"name":"Cardiovascular Center Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Maternal\u2010Fetal Medicine Advocate Aurora Health  Downers Grove Illinois 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