{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:44:12Z","timestamp":1791989052647,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U24NS107237"],"award-info":[{"award-number":["U24NS107237"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012292","name":"Gerstner Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012292","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Pregnancy\u2010related reversible cerebral vasoconstriction syndrome (RCVS) has higher rates of intracerebral complications and mortality compared to non\u2010pregnant RCVS. Case reports suggest preeclampsia\u2010eclampsia as an important risk factor; however, data are limited regarding this association. We hypothesized that pregnancy\u2010related RCVS is strongly associated with preeclampsia\u2010eclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a single\u2010center, retrospective, case\u2010control study to estimate the association between preeclampsia\u2010eclampsia and RCVS. Cases between January 1, 2010, and June 30, 2024, were identified from hospital billing data and defined as RCVS in pregnancy or postpartum (&lt;12\u00a0weeks) based on the combination of (1) typical clinical presentation, (2) \u22651 imaging modality consistent with vasoconstriction, and (3) the absence of an alternative diagnosis. Controls were pregnant or postpartum patients selected randomly from our hospital quality database and matched with cases (3:1 ratio) for delivery month and year. The primary exposure was preeclampsia\u2010eclampsia diagnosed preceding or concurrent with the RCVS diagnosis. We created logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (95% CI) for the association of preeclampsia\u2010eclampsia with RCVS, adjusting for confounders. We calculated the fraction of RCVS attributable to preeclampsia\u2010eclampsia using the unadjusted OR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 40 RCVS cases and 120 controls. Age, delivery mode, gestational and chronic hypertension, and peripartum complications did not differ between groups. Preterm birth (20.6%\u00a0vs. 8.3%,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001) and preeclampsia\u2010eclampsia (73%\u00a0vs. 10%,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001) were more prevalent in cases compared to controls. Most RCVS (80%) and preeclampsia\u2010eclampsia (62%) occurred postpartum. Antepartum RCVS occurred at a median of 30\u00a0weeks (interquartile range [IQR] 20\u201333). Fifty\u2010five percent of RCVS cases had associated intracranial complications such as hemorrhage, infarction, or posterior reversible encephalopathy syndrome, 45% required intensive care, and 15% were discharged to rehabilitation. Adjusting for gravidity, pregnancy length, and timing of preeclampsia\u2010eclampsia diagnosis (antepartum, intrapartum, or postpartum), preeclampsia\u2010eclampsia was associated with increased odds of RCVS (adjusted OR [aOR], 37.1; 95% CI, 10.6\u2013129.9;\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001). The fraction of RCVS attributable to preeclampsia\u2010eclampsia was 95%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Preeclampsia\u2010eclampsia is associated with increased odds of pregnancy\u2010related RCVS, suggesting possible shared mechanisms. Prospective studies of preeclampsia\u2010eclampsia patients, including neurovascular imaging, are needed to confirm these findings and explore the underlying pathophysiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pmf2.70253","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T06:24:26Z","timestamp":1770359066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between preeclampsia and reversible cerebral vasoconstriction syndrome: A case\u2010control study"],"prefix":"10.1002","volume":"2","author":[{"given":"Srinath","family":"Ramaswamy","sequence":"first","affiliation":[{"name":"Department of Neurology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noora","family":"Haghighi","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney A.","family":"Booker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malamo","family":"Countouris","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea D.","family":"Shields","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Connecticut Health Center  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua Z.","family":"Willey","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randolph S.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7108-8906","authenticated-orcid":false,"given":"Eliza C.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Irving Medical Center  New York New York USA"},{"name":"Department of Neurology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930231181250"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24652"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41983-023-00607-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1586\/erc.10.124"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2025.111157"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000214"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.3.326"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/str.19.12.1572a"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.08821"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199611143352002"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08403.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2019.01.009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X14567976"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/neurolint14020040"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.811"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.046312"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2019.08.014"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000116388"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4768"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(87)90251-5"},{"key":"e_1_2_9_22_1","first-page":"207","volume-title":"Stroke: Pathophysiology, Diagnosis And Management","author":"Meairs S.","year":"1998"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1982.57.6.0769"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003891"},{"key":"e_1_2_9_25_1","volume-title":"Severe Maternal Morbidity","author":"Centers for Disease Control and Prevention"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012223"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113439"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.639575"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S168569"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2109523"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-013-0395-7"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.10.027"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11425-z"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.15441\/ceem.15.099"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.09.037"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-021-00958-z"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-013-1307-9"},{"key":"e_1_2_9_38_1","unstructured":"Dawson E. L. andM. J.Khoury.2022.Preeclampsia Genomics and Public Health. Accessed June 24 2025.https:\/\/blogs.cdc.gov\/genomics\/2022\/10\/25\/preeclampsia\/."}],"container-title":["Pregnancy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmf2.70253","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pmf2.70253","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmf2.70253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:44:19Z","timestamp":1791985459000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pmf2.70253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/pmf2.70253"],"URL":"https:\/\/doi.org\/10.1002\/pmf2.70253","archive":["Portico"],"relation":{},"ISSN":["2997-9684","2997-9684"],"issn-type":[{"value":"2997-9684","type":"print"},{"value":"2997-9684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]},"assertion":[{"value":"2025-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70253"}}