{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:07:48Z","timestamp":1784290068404,"version":"3.55.0"},"reference-count":70,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Previous research has shown that preventive counseling for women at high risk of perinatal depression leads to a reduction in the development of perinatal depression and is cost\u2010effective. Barriers of cost, transit, time, and staffing limit accessibility of these services. We examined whether a theoretical, virtual, group, social worker (SW)\u2010led Mindfulness\u2010Based Cognitive Therapy (MBCT) program for patients at high risk of perinatal depression would be cost\u2010effective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>We developed a decision\u2010analytic model using TreeAge to compare outcomes in pregnant patients at high risk of perinatal depression who received a preventive virtual group MBCT curriculum versus standard care. We used a theoretical cohort of 469,000 patients, representing the number of annual pregnancies to individuals with a history of depression in the United States. Outcomes included postpartum depression, maternal suicide, postpartum psychosis, preterm birth, neonatal death, and neurodevelopmental delay in addition to cost and quality\u2010adjusted life years (QALYs). The willingness\u2010to\u2010pay threshold was set to $100,000\/QALY. Literature searches were used to identify model inputs, and sensitivity analyses were conducted to assess model robustness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Within the theoretical cohort of 469,000 people, the virtual, group, SW\u2010led MBCT curriculum prevented 26,180 cases of postpartum depression, 1 maternal suicide, 2 cases of postpartum psychosis, 4044 preterm deliveries, 39 neonatal deaths, and 47 cases of neurodevelopmental delay. The MBCT strategy led to lower costs (saving $152,496,858) and better outcomes (15,052 gained QALYs), making it cost\u2010saving. Sensitivity analyses demonstrated that MBCT remained cost\u2010saving until treatment reached $800, and cost\u2010effective until $4014, both of which were significantly higher than the expected cost of MBCT delivery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found that virtual SW\u2010led group MBCT led to better outcomes and lower costs for pregnant patients at high risk of depression. Given these findings, the benefits to high\u2010risk patients, and the shortage of mental health providers, such preventive mental health models should be examined for broader implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pmf2.70305","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:24:48Z","timestamp":1779186288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost\u2010effectiveness of virtual Mindfulness\u2010Based Cognitive Therapy on pregnancies at high risk of perinatal depression"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4861-399X","authenticated-orcid":false,"given":"Riane","family":"Bradbury\u2010Huang","sequence":"first","affiliation":[{"name":"Department of Psychology Barnard College of Columbia University  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2271-105X","authenticated-orcid":false,"given":"Lindsay","family":"Quinn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Oregon Health and Science University Portland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2457-1807","authenticated-orcid":false,"given":"Ellen L.","family":"Tilden","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Oregon Health and Science University Portland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1752-0972","authenticated-orcid":false,"given":"Aaron B.","family":"Caughey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Oregon Health and Science University Portland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6919a2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.16121"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-021-03684-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","unstructured":"Elgaddal N. 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