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The underlying pathophysiology is unclear, but impaired cerebral autoregulation may contribute to adverse maternal outcomes. Long\u2010term consequences of preeclampsia include cerebrovascular disease, and impairment of cerebral autoregulation could contribute to these outcomes. The aim of this study was to assess cerebral autoregulation in women with preeclampsia and normotensive pregnancies during pregnancy and 1\u2010year postpartum to quantify impairment during disease and evaluate its persistence or recovery over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter, prospective, observational cohort study included women from the UPMOST or GoPROVE studies. Women with preeclampsia were examined at diagnosis. Participants underwent transcranial Doppler examinations at inclusion and 1\u2010year postpartum. Women were categorized as having normotensive pregnancies or preeclampsia with or without maternal complications. Cerebral autoregulation was assessed by the autoregulation index (ARI). Differences in mean ARI between and within groups were analyzed using regression models for repeated measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 124 women were included in the analysis. During pregnancy, mean ARI was higher in normotensive pregnancies compared with preeclampsia (6.90 [SD, 0.77] vs. 6.12 [SD, 1.45]; mean difference 0.78 [95% CI, 0.37\u20131.19]), but no difference was observed 1\u2010year postpartum (6.11 [SD, 1.14] vs. 6.15 [SD, 1.10]; mean difference \u22120.03 [95% CI, \u22120.47 to 0.54]). Mean ARI did not differ between preeclampsia with or without severe features, either during pregnancy (6.24 [SD, 1.49] vs. 5.98 [SD, 1.40]; mean difference 0.27 [95% CI, \u22120.43 to 0.96]), or 1\u2010year postpartum (6.13 [SD, 1.23] vs. 6.18 [SD, 0.94]; mean difference \u22120.05 [95% CI, \u22120.64 to 0.54]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preeclampsia impairs the autoregulatory advantage offered by pregnancy. This renders the maternal brain more vulnerable to neurovascular injury. This impairment appears to resolve by 1\u2010year postpartum, suggesting that persistently depressed cerebral autoregulation is unlikely to account for long\u2010term cerebrovascular consequences of preeclampsia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pmf2.70324","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:31:46Z","timestamp":1780371106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebral autoregulation in normal pregnancy, preeclampsia, and 1\u2010year postpartum"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0754-549X","authenticated-orcid":false,"given":"Niclas","family":"Carlberg","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Sahlgrenska University Hospital \u00d6stra  Gothenburg Sweden"},{"name":"Department of Obstetrics and Gynecology Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Junus","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"},{"name":"Department of Obstetrics and Gynecology Uppsala University Hospital  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Karin","family":"Wikstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"},{"name":"Department of Obstetrics and Gynecology Uppsala University Hospital  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5202-9428","authenticated-orcid":false,"given":"Lina","family":"Bergman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"},{"name":"Department of Obstetrics and Gynecology Stellenbosch University  Cape Town South Africa"},{"name":"Department of Obstetrics and Gynecology Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karusha","family":"Knipe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Stellenbosch University  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Cluver","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Stellenbosch University  Cape Town South 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