{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:01:58Z","timestamp":1790766118438,"version":"4.1.0"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD001259\u201026"],"award-info":[{"award-number":["HD001259\u201026"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pregnancy"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The majority of low placentation identified on first\u2010trimester transabdominal ultrasound resolves; however, whether this resolution is associated with adverse outcome remains poorly understood. This investigation aimed to determine whether patients with resolved first\u2010trimester low placentation had different delivery outcomes compared to patients who never had low placentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective cohort study of singleton pregnancies with low placentation, defined as low\u2010lying placenta or placenta covering the internal os, on first\u2010trimester transabdominal ultrasound between 12+0\u00a0weeks and 13+6\u00a0weeks, delivering at a single tertiary care center from January to December 2022. We compared outcomes stratified by first\u2010trimester low placentation that resolved by the second trimester, or those without low placentation at any point. The primary outcome was quantitative blood loss at delivery by volumetric measurement. Secondary outcomes included postpartum hemorrhage (PPH) defined as blood loss \u22651000 cc, unplanned cesarean delivery, preterm birth, 5\u2010min Apgar\u00a0&lt;\u00a07, and composite maternal adverse outcomes including the use of atony device, retained products of conception, blood transfusion, peripartum hysterectomy, intensive care unit admission, or death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This cohort included 437 low placentation patients and 491 patients without low placentation. Resolved first\u2010trimester low placentation was associated with a significant increase in quantitative blood loss at delivery (405\u00a0\u00b1\u00a0369 cc vs. 331\u00a0\u00b1\u00a0253 cc,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) but no difference in incidence of PPH (6.4% vs. 4.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.25). Resolved first\u2010trimester low placentation was also associated with increased tranexamic acid (TXA) administration (11.9% vs. 7.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03), blood transfusion (1.8% vs. 0.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.04), and unplanned cesarean delivery (15.3% vs. 9.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) without differences in the indications for unplanned cesarean delivery. In our multivariable regression, resolved first\u2010trimester low placentation remained associated with TXA administration (adjusted odds ratio [OR], 1.70; 95% confidence interval [CI], 1.07\u20132.70) and unplanned cesarean delivery (adjusted OR 1.73; 95% CI, 1.12\u20132.68). There were no associations with adverse neonatal outcomes or composite maternal outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Resolved first\u2010trimester low placentation is not associated with clinically significant adverse outcomes. However, given changes in unplanned cesarean delivery rate, resolved low placentation may indicate altered uterine physiology. Future research would be valuable to better understand the relationship between resolved low placentation and unplanned cesarean deliveries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pmf2.70368","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T08:17:18Z","timestamp":1784017038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Delivery outcomes associated with resolved first\u2010trimester low placentation"],"prefix":"10.1002","volume":"2","author":[{"given":"Rachel","family":"Feiner","sequence":"first","affiliation":[{"name":"School of Medicine University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2158-4482","authenticated-orcid":false,"given":"Rachel","family":"Wiley","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology and Reproductive Science University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Lamale\u2010Smith","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology and Reproductive Science University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Nicole","family":"Teal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology and Reproductive Science University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2677-3023","authenticated-orcid":false,"given":"Minhazur","family":"Sarker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology and Reproductive Science University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610410001722545"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15687"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170194"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2025.01.035"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.24825"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20101877\u20108617"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102572\u20101646"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000245"}],"container-title":["Pregnancy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmf2.70368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pmf2.70368","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmf2.70368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:21:27Z","timestamp":1790763687000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pmf2.70368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/pmf2.70368"],"URL":"https:\/\/doi.org\/10.1002\/pmf2.70368","archive":["Portico"],"relation":{},"ISSN":["2997-9684","2997-9684"],"issn-type":[{"value":"2997-9684","type":"print"},{"value":"2997-9684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70368"}}