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We tested hierarchical structural models to further validate a portion of the structural components of HiTOP. We also tested a priori personality and psychopathology associations with three levels of the HiTOP hierarchy: general psychopathology, spectra and syndromes\/disorders. We used a large sample from the general Australian population who completed a large set of personality and psychopathology inventories online. Confirmatory factor analyses indicated that internalizing, externalizing and thought dysfunction spectra emerged structurally, as expected per HiTOP, but also revealed that obsessive\u2010compulsive disorder loaded on both internalizing and thought dysfunction and attention deficit hyperactivity disorder on both externalizing and internalizing. Furthermore, results indicated that almost all personality and psychopathology hypotheses were supported, although trait antagonism did not predict externalizing to the degree initially expected. Implications for personality and psychopathology are discussed. \u00a9 2019 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pmh.1461","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T09:08:28Z","timestamp":1565341708000},"page":"30-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The role of maladaptive personality domains across multiple levels of the <scp>HiTOP<\/scp> structure"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2883-6163","authenticated-orcid":false,"given":"Martin","family":"Sellbom","sequence":"first","affiliation":[{"name":"Department of Psychology University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha","family":"Carragher","sequence":"additional","affiliation":[{"name":"Prince of Wales Clinical School University of New South Wales  Sydney 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