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Individuals in the current study included 705 adults with OCD who had participated in family and genetic studies of the disorder. Participants self\u2010completed the Neuroticism, Extraversion, Openness Personality Inventory or Neuroticism, Extraversion, Openness Five\u2010Factor Inventory\u20103. Relationships between personality scores, and subjective impairment and OCD treatment response, were evaluated. The odds of subjective impairment increased with (unit increase in) the neuroticism score (odds ratio, OR = 1.03; 95% CI = 1.01\u20131.04; <jats:italic>p<\/jats:italic> &lt; 0.01) and decreased with extraversion scores (OR = 0.98; 95% CI = 0.96\u20130.99; <jats:italic>p<\/jats:italic> &lt; 0.01). The odds of reporting a good response to serotonin\/selective serotonin reuptake inhibitors (OR = 1.02; 95% CI = 1.01\u20131.04; <jats:italic>p<\/jats:italic> &lt; 0.01) or cognitive behavioural therapy (OR = 1.03; 95% CI = 1.01\u20131.05; <jats:italic>p<\/jats:italic> &lt; 0.01) increased with the extraversion score. The magnitude of these relationships did not change appreciably after adjusting for other clinical features related to one or more of the personality dimensions. The findings suggest that neuroticism and extraversion are associated with subjective impairment, and that extraversion is associated with self\u2010reported treatment response, in individuals with OCD. \u00a9 2019 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pmh.1472","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T12:21:31Z","timestamp":1576844491000},"page":"186-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["General personality dimensions, impairment and treatment response in obsessive\u2013compulsive disorder"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6715-7905","authenticated-orcid":false,"given":"Jack","family":"Samuels","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. 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