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Over 30\u2009years, patients with dependent and anankastic personality disturbance and cothymia (the general neurotic syndrome) were 2.27 times more likely to receive selective serotonin reuptake inhibitors (SSRIs) and new antidepressants (95% confidence interval [CI]: 1.22\u20134.24), particularly paroxetine, and were 1.6\u2009weeks (95% CI: 1.2\u20132.3) longer on the drug than those without the syndrome. Similar results with SSRIs and new antidepressants in patients with personality disorder fell short of significance after adjusting for age, sex and DSM status. Most patients had a DSM diagnosis at follow\u2010up points, and these had increased psychological treatment, psychiatric admissions, multiple drugs, SSRIs and new antidepressants. At later follow\u2010up, most drug treatments decreased apart from psychological treatment, SSRIs and new antidepressants, and baseline personality disorder had little impact on treatment histories compared with others. We conclude that the (Galenic) general neurotic syndrome is associated with greater use of treatments in the long term, showing that combined personality and symptomatic pathology overcomes that of personality disorder alone.<\/jats:p>","DOI":"10.1002\/pmh.1535","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T05:23:12Z","timestamp":1641273792000},"page":"99-110","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Relationships between treatments received in the Nottingham Study of Neurotic Disorder over 30\u2009years and personality status"],"prefix":"10.1002","volume":"16","author":[{"given":"Peter","family":"Tyrer","sequence":"first","affiliation":[{"name":"Division of Psychiatry Imperial College London  London UK"},{"name":"Personality Disorder Service, Lincolnshire Partnership NHS Foundation Trust  Lincoln UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Tyrer","sequence":"additional","affiliation":[{"name":"Division of Psychiatry Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"West China School of Public Health Sichuan University  Chengdu China"},{"name":"Faculty of Health, Art and Design Swinburne University of Technology  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3399\/BJGPO.2021.0020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-013-0746-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0706743717700818"},{"key":"e_1_2_9_5_1","volume-title":"Schedule for nonadaptive and adaptive personality\u2014Second edition","author":"Clark L. 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