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This study investigated the associations of the general and specific psychopathology factors with multiple personality trait hierarchy levels: broad domains, their facets and nuances (<jats:italic>N<\/jats:italic>\u2009=\u20091839 Estonian adults). A bi\u2010factor model with a general \u2018<jats:italic>p<\/jats:italic>\u2019 factor and specific factors for internalising problems, thought disorders and substance use best represented psychopathology structure. Although traits' predictive accuracy varied across psychopathology factors, nuances (the lowest level personality units) provided higher predictive accuracy and higher discriminant validity than domains. For example, traits related to high vulnerability, depression and immoderation and low friendliness and achievement striving were most strongly associated with the <jats:italic>p<\/jats:italic> factor. Nuances may prove useful for predicting and understanding general and specific psychopathology forms.<\/jats:p>","DOI":"10.1002\/pmh.1561","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T09:55:07Z","timestamp":1660298107000},"page":"67-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Investigating general and specific psychopathology factors with nuance\u2010level personality traits"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2970-0399","authenticated-orcid":false,"given":"Yuzhan","family":"Hang","sequence":"first","affiliation":[{"name":"Department of Psychology University of Edinburgh  Edinburgh UK"},{"name":"Department of Psychology University of Science and Technology of China  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia Gabriela","family":"Speyer","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Edinburgh  Edinburgh UK"},{"name":"Department of Psychology University of Cambridge  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liina","family":"Haring","sequence":"additional","affiliation":[{"name":"Psychiatry Clinic of Tartu University Hospital, Institute of Clinical Medicine University of Tartu  Tartu Estonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aja Louise","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"M\u00f5ttus","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Edinburgh  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0109-2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbn135"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2167702613497473"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000193"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1027\/1015-5759\/a000626"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1521\/pedi.1992.6.4.343"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00770"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v033.i01"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","unstructured":"Gibbons A. 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