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Here, we carried out a cross\u2010sectional study in a sample comprising 303 Caucasian polydrug\u2010consuming patients. The presence of personality disorders was evaluated using the International Personality Disorder Examination, and genes related to dopamine, serotonin and monoamine oxidase (MAO) were genotyped. A significant relationship was observed between the bp 279 <jats:italic>DRD5<\/jats:italic> variable number of tandem repeat (VNTR) polymorphism and paranoid personality disorder \n. The bp 182 \n and bp 184 \n alleles of the <jats:italic>MAOB<\/jats:italic> VNTR were also associated with antisocial personality disorder. Among patients with addictions, paranoid personality disorder should also be considered in addition to the importance of antisocial and borderline personality disorders. The higher frequency of the bp 279 <jats:italic>DRD5<\/jats:italic> VNTR allele found in patients with paranoid personality disorder, as well as the associations between alleles of the <jats:italic>MAOB<\/jats:italic> VNTR and antisocial personality disorder, support the monoaminergic bases of these personality disorders, especially when dealing with patients with addictions.<\/jats:p>","DOI":"10.1002\/pmh.1563","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T02:49:41Z","timestamp":1660358981000},"page":"77-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Relationship of DRD5 and MAO\u2010B VNTR polymorphisms with paranoid and antisocial personality disorders in polydrug users"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8257-0183","authenticated-orcid":false,"given":"Marcelo","family":"O'Higgins","sequence":"first","affiliation":[{"name":"Department of Psychiatry, School of Medical Sciences National University of Asunci\u00f3n  San Lorenzo Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0785-3570","authenticated-orcid":false,"given":"Ana","family":"Benito","sequence":"additional","affiliation":[{"name":"TXP Research Group, Medicine and Surgery Department Universidad Cardenal Herrera\u2010CEU, CEU Universities  Castell\u00f3 Spain"},{"name":"Mental Health Unit of Torrent Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0975-5875","authenticated-orcid":false,"given":"Mat\u00edas","family":"Real\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Pre\u2010department Medicine Unit Universitat Jaume I  Castell\u00f3 Spain"},{"name":"Severe Mental Disorder in Childhood and Adolescence Program, Mental Health Department Consorcio Hospitalario Provincial de Castell\u00f3  Castell\u00f3 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-8804","authenticated-orcid":false,"given":"Isis","family":"Gil\u2010Miravet","sequence":"additional","affiliation":[{"name":"TXP Research Group, Medicine and Surgery Department Universidad Cardenal Herrera\u2010CEU, CEU Universities  Castell\u00f3 Spain"},{"name":"Pre\u2010department Medicine Unit Universitat Jaume I  Castell\u00f3 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3502-2731","authenticated-orcid":false,"given":"Enrique","family":"Ochoa","sequence":"additional","affiliation":[{"name":"Molecular Biopathology Department Consorcio Hospitalario Provincial de Castell\u00f3  Castell\u00f3 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1299-9611","authenticated-orcid":false,"given":"Gonzalo","family":"Haro","sequence":"additional","affiliation":[{"name":"TXP Research Group, Medicine and Surgery Department Universidad Cardenal Herrera\u2010CEU, CEU Universities  Castell\u00f3 Spain"},{"name":"Severe Dual Pathology Program, Mental Health Department Consorcio Hospitalario Provincial de Castell\u00f3  Castell\u00f3 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jopy.12397"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/27.2.573"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmh.1244"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1521\/pedi_2013_27_123"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-018-0934-7"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.1.70"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.114.144964"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.23201"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009734.2018.1526235"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/385590a0"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3758\/BRM.41.4.1149"},{"key":"e_1_2_10_13_1","volume-title":"Antisocial personality disorder","author":"Fisher K. 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