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ANA\u2010positive sera from 29 patients with AIH1 and 14 negative controls were analyzed by sodium dodecyl sulfate\u2010polyacrylamide gel electrophoresis (SDS\u2010PAGE) and immunoblotting. The principal antigens identified were a 30\u00a0kDa triplet band which was recognized by 79% of patient sera and 14% of control sera, and a 36\u00a0kDa antigen which was recognized by 52% and 14% of sera, respectively. The latter antigen was studied in more detail using two\u2010dimensional electrophoresis (2\u2010DE) and mass spectrometry (MS). Its identification corresponded to heterogeneous nuclear ribonucleoprotein A2\/B1. This paper presents the first description of this protein as an antigen in AIH1.<\/jats:p>","DOI":"10.1002\/pmic.200300757","type":"journal-article","created":{"date-parts":[[2004,3,30]],"date-time":"2004-03-30T05:17:33Z","timestamp":1080623853000},"page":"1341-1345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Heterogeneous nuclear ribonucleoprotein A2\/B1 identified as an autoantigen in autoimmune hepatitis by proteome analysis"],"prefix":"10.1002","volume":"4","author":[{"given":"St\u00e8phanie","family":"Huguet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e8rie","family":"Labas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Charles","family":"Duclos\u2010Vallee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Bruneel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Vinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Samuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Johanet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Ballot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,4,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80297-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80425-0"},{"key":"e_1_2_1_4_2","first-page":"66","author":"Robinson W. 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