{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:31:46Z","timestamp":1791307906914,"version":"4.3.1"},"reference-count":71,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2005,10,5]],"date-time":"2005-10-05T00:00:00Z","timestamp":1128470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The protein composition of the crude venoms of the three most important vipers of Tunisia was analyzed by RP\u2010HPLC, N\u2010terminal sequence analysis, MALDI\u2010TOF mass determination, and in\u2010gel tryptic digestion followed by PMF and CID\u2010MS\/MS of selected peptide ions in a quadrupole\u2010linear IT instrument. Our results show that the venom proteomes of\n                    <jats:italic>Cerastes cerastes<\/jats:italic>\n                    ,\n                    <jats:italic>Cerastes vipera<\/jats:italic>\n                    , and\n                    <jats:italic>Macrovipera lebetina<\/jats:italic>\n                    are composed of proteins belonging to a few protein families. However, each venom showed distinct degree of protein composition complexity. The three venoms shared a number of protein classes though the relative occurrence of these toxins was different in each snake species. On the other hand, the venoms of the\n                    <jats:italic>Cerastes<\/jats:italic>\n                    species and\n                    <jats:italic>Macrovipera lebetina<\/jats:italic>\n                    each contained unique components. The comparative proteomic analysis of Tunisian snake venoms provides a comprehensible catalogue of secreted proteins, which may contribute to a deeper understanding of the biological effects of the venoms, and may also serve as a starting point for studying structure\u2010function correlations of individual toxins.\n                  <\/jats:p>","DOI":"10.1002\/pmic.200402024","type":"journal-article","created":{"date-parts":[[2005,10,5]],"date-time":"2005-10-05T05:16:27Z","timestamp":1128489387000},"page":"4223-4235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["Snake venomics: Comparative analysis of the venom proteomes of the Tunisian snakes\n                    <b>\n                      <i>Cerastes cerastes<\/i>\n                    <\/b>\n                    ,\n                    <b>\n                      <i>Cerastes vipera<\/i>\n                    <\/b>\n                    and\n                    <b>\n                      <i>Macrovipera lebetina<\/i>\n                    <\/b>"],"prefix":"10.1002","volume":"5","author":[{"given":"Amine","family":"Bazaa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naziha","family":"Marrakchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El Ayeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libia","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Calvete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10,27]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(98)00126-3"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(98)00125-1"},{"key":"e_1_2_1_4_2","volume-title":"Perspectives in Molecular Toxinology","author":"M\u00e9nez A.","year":"2002"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200300628"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20021739"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(01)00289-6"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02338834"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(96)01144-1"},{"key":"e_1_2_1_10_2","first-page":"63","volume-title":"Envenoming and their Treatments","author":"Warrell D. 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