{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:17:14Z","timestamp":1767136634554,"version":"build-2238731810"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,1,10]],"date-time":"2006-01-10T00:00:00Z","timestamp":1136851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    is known to cause chronic gastritis, peptic ulcer, and gastric cancer, and has also been linked to iron deficiency anemia\u2005(IDA). To determine whether\n                    <jats:italic>H.\u2005pylori<\/jats:italic>\n                    clinical isolates correlate with the prevalence of\n                    <jats:italic>H.\u2005pylori<\/jats:italic>\n                    \u2010associated IDA, we compared the proteomic profiles of\n                    <jats:italic>H.\u2005pylori<\/jats:italic>\n                    strains isolated from antral biopsy specimens of\n                    <jats:italic>H.\u2005pylori<\/jats:italic>\n                    \u2010positive patients with or without IDA. Fifteen strains, including eight non\u2010IDA and seven IDA strains, were cultured under iron\u2010rich and iron\u2010depleted conditions and then analyzed for protein expression profiles by 2\u2010DE. The distances between two\n                    <jats:italic>H.\u2005pylori<\/jats:italic>\n                    strains were determined on the basis of similarities between their expression patterns of 189 protein spots, and a phylogenetic tree was constructed. The results revealed that the IDA strains formed a cluster separate from that of six non\u2010IDA strains, with two non\u2010IDA strains between the clusters.\n                    <jats:italic>H.\u2005pylori<\/jats:italic>\n                    strain\u200526695 was located in the non\u2010IDA cluster. Protein spots displaying similar expression patterns were clustered, and 18\u2009spots predominantly expressed in IDA strains were identified by MALDI\u2010TOF analysis. These data indicate that the non\u2010IDA and IDA strains can be distinguished by their protein expression profiles, suggesting that the polymorphism of\n                    <jats:italic>H.\u2005pylori<\/jats:italic>\n                    strains may be one of the factors determining the occurrence of\n                    <jats:italic>H.\u2005pylori<\/jats:italic>\n                    \u2010associated IDA.\n                  <\/jats:p>","DOI":"10.1002\/pmic.200500293","type":"journal-article","created":{"date-parts":[[2006,1,10]],"date-time":"2006-01-10T13:48:53Z","timestamp":1136900933000},"page":"1319-1328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Comparative proteomic analysis of\n                    <b>\n                      <i>Helicobacter pylori<\/i>\n                    <\/b>\n                    strains associated with iron deficiency anemia"],"prefix":"10.1002","volume":"6","author":[{"given":"Shin Ae","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyang Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung Hee","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Wook","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yon Ho","family":"Choe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo Young","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang Je","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Su Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na Gyong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.4.720"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1083-4389.2002.00073.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(00)00288-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.1999.98066.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2000.tb01208.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70192-1"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.4.496"},{"key":"e_1_2_1_9_2","first-page":"533","volume":"89","author":"Ruiz B.","year":"1994","journal-title":"Am. 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