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It was the aim of this hypothesis\u2010generating study to construct differential proteomes of bronchial biopsies in controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) and CF patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a09). Biopsies (pools of three <jats:italic>per<\/jats:italic> patient) were taken; proteins were extracted and run on 2\u2010DE with subsequent in\u2010gel digestion and mass spectrometrical identification and quantification of proteins using specific software. Three hundred sixty\u2010six protein spots were identified and compared between groups. Following an approach for multiple testing correction, the chaperone 75\u2005kDa glucose\u2010regulated protein and ubiquinol\u2013cytochrome\u2005c reductase complex core protein\u2005I and one form of nidogen, a pseudogene of aconitase\u20052, were increased in CF (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.005). Aberrant protein levels may reflect molecular changes of CF as well as CF\u2010linked inflammation, infection and cellular stress response.<\/jats:p>","DOI":"10.1002\/pmic.200500487","type":"journal-article","created":{"date-parts":[[2006,4,24]],"date-time":"2006-04-24T12:58:48Z","timestamp":1145883528000},"page":"3381-3388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Possible dysregulation of chaperon and metabolic proteins in cystic fibrosis bronchial tissue"],"prefix":"10.1002","volume":"6","author":[{"given":"Thomas","family":"Frischer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Kyung","family":"Myung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irmgard","family":"Eichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Szepfalusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Lubec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200401120"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-003-0060-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2004.05.008"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2004.03.014"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2003.09.005"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200400850"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5934-0_44"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2001.02256.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683()22:6<1233::AID-ELPS1233>3.0.CO;2-M"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305809"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2005.04.017"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.99.14511369"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2004.06.017"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00291-7"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C300135200"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20168"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200410065"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.23.6879"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00149.2002"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.13a20.x"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2003.12.005"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.37.040103.103949"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.120.7.2003"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.058503"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00316.2002"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00253.2002"},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1183\/09031936.93.03030261","volume":"3","author":"Sonderberg M.","year":"1990","journal-title":"Eur. 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