{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:17:35Z","timestamp":1767961055358,"version":"3.49.0"},"reference-count":58,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,5,18]],"date-time":"2007-05-18T00:00:00Z","timestamp":1179446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pineal gland secretes the hormone melatonin. This secretion exhibits a circadian rhythm with a zenith during night and a nadir during day. We have performed proteome analysis of the superficial pineal gland in rats during daytime and nighttime. The proteins were extracted and subjected to 2\u2010DE. Of 1747 protein spots revealed by electrophoresis, densitometric analysis showed the up\u2010regulation of 25 proteins during nighttime and of 35 proteins during daytime. Thirty\u2010seven of the proteins were identified by MALDI\u2010TOF MS. The proteins up\u2010regulated during the night are involved in the Krebs cycle, energy transduction, calcium binding, and intracellular transport. During the daytime, enzymes involved in glycolysis, electron transport, and also the Krebs cycle were up\u2010regulated as well as proteins taking part in RNA binding and RNA processing. Our data show a prominent day\u2013night variation of the protein levels in the rat pineal gland. Some proteins are up\u2010regulated during the night concomitant with the melatonin secretion of the gland. Other proteins are up\u2010regulated during the day indicating a pineal metabolism not related to the melatonin synthesis.<\/jats:p>","DOI":"10.1002\/pmic.200600963","type":"journal-article","created":{"date-parts":[[2007,5,19]],"date-time":"2007-05-19T04:02:45Z","timestamp":1179547365000},"page":"2009-2018","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Proteomic analysis of day\u2013night variations in protein levels in the rat pineal gland"],"prefix":"10.1002","volume":"7","author":[{"given":"Morten","family":"M\u00f8ller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Sparre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolai","family":"Bache","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Roepstorff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Vorum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-1-2-109"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-58932-4_1"},{"key":"e_1_2_1_4_2","first-page":"345","volume-title":"Neuroendocrine Perspectives","author":"Reiter R. J.","year":"1983"},{"key":"e_1_2_1_5_2","first-page":"307","volume":"52","author":"Klein D. C.","year":"1977","journal-title":"Recent Prog. Horm. Res."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/074873001129001980"},{"key":"e_1_2_1_7_2","first-page":"311","volume":"61","author":"Tricoire H.","year":"2003","journal-title":"Reprod. Suppl."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0739-7240(02)00148-0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.01001.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.169.3950.1093"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.184.4144.1341"},{"key":"e_1_2_1_12_2","first-page":"1","volume":"7","author":"M\u00f8ller M.","year":"1994","journal-title":"Adv. Pineal Res."},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(95)00046-B"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)62952-0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1988.tb00800.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01252810"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01250053"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00331366"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408438200"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414587200"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03773.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1615-9861(200111)1:11<1359::AID-PROT1359>3.0.CO;2-Q"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1615-9861(200207)2:7<928::AID-PROT928>3.0.CO;2-P"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9888(199902)34:2<105::AID-JMS768>3.0.CO;2-4"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(01)01954-5"},{"key":"e_1_2_1_26_2","first-page":"49","volume":"367","author":"Hjern\u00f8 K.","year":"2006","journal-title":"Methods Mol. Biol."},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9888(200012)35:12<1399::AID-JMS86>3.0.CO;2-R"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9542193"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01627.x"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-09-03326.1999"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-002-0579-y"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00324-9"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.062585499"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2683(19990101)20:4\/5<643::AID-ELPS643>3.0.CO;2-M"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150180333"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.3.1720"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1990.tb00900.x"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1984.tb00224.x"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00217142"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1992.tb00041.x"},{"key":"e_1_2_1_41_2","first-page":"130","volume":"70","author":"Suzuki T.","year":"1995","journal-title":"Kaibogaku Zasshi"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00689608"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-5-4-219"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(94)90002-7"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90238-5"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01244968"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.131.4.1895"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1996.tb00284.x"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197605)37:5<2343::AID-CNCR2820370525>3.0.CO;2-H"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01419502"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-197910000-00015"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199803300-00003"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713688609015122"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90234-2"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1080\/07420520500521855"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-079X.2003.00054.x"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.6272"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(67)90226-3"},{"key":"e_1_2_1_59_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0760547"}],"container-title":["PROTEOMICS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpmic.200600963","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmic.200600963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:04:39Z","timestamp":1761048279000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pmic.200600963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":58,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1002\/pmic.200600963"],"URL":"https:\/\/doi.org\/10.1002\/pmic.200600963","archive":["Portico"],"relation":{},"ISSN":["1615-9853","1615-9861"],"issn-type":[{"value":"1615-9853","type":"print"},{"value":"1615-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"2006-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-06-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}