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The lithium pilocarpine model of status epilepticus (SE) in the rat provides a model in which to investigate the molecular and pathogenic process leading to hippocampal damage. In this study, a 2\u2010DE\u2010based approach was used to detect proteome changes in the hippocampus, at an early stage (2\u2005days) after SE, when increased T<jats:sub>2<\/jats:sub> values were detectable by magnetic resonance imaging. Gel image analysis was followed by LC\u2010MS\/MS identification of protein species that differed in abundance between pilocarpine\u2010treated and control rats. The most significantly up\u2010regulated species in the experimental animals was identified as heat shock 27\u2010kDa protein, in line with findings in humans and in other experimental models of epilepsy. Additional up\u2010regulated species included dihydropyrimidinase\u2010related protein\u20102, cytoskeletal proteins (\u03b1\u2010tubulin and ezrin) and dihydropteridine reductase. In summary, the hippocampus of rats subject to pilocarpine\u2010induced SE exhibits specific changes in protein abundance, which likely relate to pathogenic, neuroprotective and neurogenic responses.<\/jats:p>","DOI":"10.1002\/pmic.200601027","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T09:48:16Z","timestamp":1173952096000},"page":"1336-1344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine\u2010induced model of convulsive status epilepticus"],"prefix":"10.1002","volume":"7","author":[{"given":"Nicholas D. 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