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Sprague\u2010Dawley rats were subjected to a full\u2010thickness dorsal burn injury covering 40% of the total body surface area. Controls consisted of sham\u2010treated animals. Liver tissues were collected on postburn days 1 and 7. The proteomic data show greater production of positive acute phase proteins on day 1 than on day 7. Many antioxidant enzymes were coordinately downregulated on day 1, including the potent biliverdin reductase. These antioxidants were restored and in some cases upregulated on day 7. This opposite trend in the change of antioxidant proteins corroborated our finding of more pronounced oxidative stress on day 1 than on day 7 as measured <jats:italic>via<\/jats:italic> protein carbonyl content. The changes of metabolic enzymes on days 1 and 7 were consistent with hypo\u2010 and hyper\u2010metabolic states, respectively. Furthermore, a previously unreported decrease in ornithine aminotransferase on day 7 may be a key contributor to the observed increased urinary urea excretion during the hypermetabolic phase. Overall, the many differences in protein expression observed on postburn days 1 and 7 reflect the dissimilar hepatic metabolic patterns during the acute and flow phases following burn injury.<\/jats:p>","DOI":"10.1002\/pmic.200700427","type":"journal-article","created":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T05:14:22Z","timestamp":1231478062000},"page":"636-647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dissimilar hepatic protein expression profiles during the acute and flow phases following experimental thermal injury"],"prefix":"10.1002","volume":"9","author":[{"given":"Xunbao","family":"Duan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Berthiaume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Yarmush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin L.","family":"Yarmush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(94)90137-6"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400607"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.12.1420"},{"key":"e_1_2_1_5_2","first-page":"465","article-title":"Inhibition of neutrophil activation by alpha1\u2010acid glycoprotein","volume":"55","author":"Costello M. 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