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We previously showed that various respiratory pathways may be used by <jats:italic>B. suis<\/jats:italic> in response to microaerobiosis and anaerobiosis. Here, we compare the whole proteome of <jats:italic>B. suis<\/jats:italic> exposed to such low\u2010oxygenated conditions to that obtained from bacteria grown under ambient air using 2\u2010D DIGE. Data showed that the reduction of basal metabolism was in line with low or absence of growth of <jats:italic>B. suis<\/jats:italic>. Under both microaerobiosis and anaerobiosis, glycolysis and denitrification were favored. In addition, fatty acid oxidation and possibly citrate fermentation could also contribute to energy production sufficient for survival under anaerobiosis. When oxygen availability changed and became limiting, basic metabolic processes were still functional and variability of respiratory pathways was observed to a degree unexpected for a strictly aerobic microorganism. This highly flexible respiration probably constitutes an advantage for the survival of <jats:italic>Brucella<\/jats:italic> under the restricted oxygenation conditions encountered within host tissue.<\/jats:p>","DOI":"10.1002\/pmic.200800266","type":"journal-article","created":{"date-parts":[[2009,6,15]],"date-time":"2009-06-15T14:08:46Z","timestamp":1245074926000},"page":"3011-3021","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Proteomic analysis of <i>Brucella suis<\/i> under oxygen deficiency reveals flexibility in adaptive expression of various pathways"],"prefix":"10.1002","volume":"9","author":[{"given":"Sascha Al","family":"Dahouk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Loisel\u2010Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger 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