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A network of reciprocal interactions between inflammatory cells, peptidic mediators, extracellular matrix components, and proteases is thought to be involved in the installation and maintenance of asthma\u2010related airway inflammation and remodeling. To date, new proteic mediators displaying significant activity in the pathophysiology of asthma are still to be unveiled. The main objective of this study was to uncover potential target proteins by using surface\u2010enhanced laser desorption\/ionization\u2010time of flight\u2010mass spectrometry (SELDI\u2010TOF\u2010MS) on lung samples from mouse models of allergen\u2010induced airway inflammation and remodeling. In this model, we pointed out several protein or peptide peaks that were preferentially expressed in diseased mice as compared to controls. 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