{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:38:45Z","timestamp":1790876325541,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,6,27]],"date-time":"2009-06-27T00:00:00Z","timestamp":1246060800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scottish Government Rural and Environment Research"},{"name":"Analysis Directorate"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The development of insulin resistance in the obese is associated with chronic, low\u2010grade inflammation. We aimed to identify novel links between obesity, insulin resistance and the inflammatory response by comparing C57BL\/6 with type I interleukin\u20101 receptor knockout (IL\u20101RI<jats:sup>\u2212\/\u2212<\/jats:sup>) mice, which are protected against diet\u2010induced insulin resistance. Mice were fed a high\u2010fat diet for 16\u2009wk. Insulin sensitivity was measured and proteomic analysis was performed on adipose, hepatic and skeletal muscle tissues. Despite an equal weight gain, IL\u20101RI<jats:sup>\u2212\/\u2212<\/jats:sup> mice had lower plasma glucose, insulin and triacylglycerol concentrations, compared with controls, following dietary treatment. The higher insulin sensitivity in IL\u20101RI<jats:sup>\u2212\/\u2212<\/jats:sup> mice was associated with down\u2010regulation of antioxidant proteins and proteasomes in adipose tissue and hepatic soluble epoxide hydrolase, consistent with a compromised inflammatory response as well as increased glycolysis and decreased fatty acid \u03b2\u2010oxidation in their muscle. Their lower hepatic triacylglycerol concentrations may reflect decreased flux of free fatty acids to the liver, decreased hepatic fatty acid\u2010binding protein expression and decreased lipogenesis. Correlation analysis revealed down\u2010regulation of classical biomarkers of ER stress in their adipose tissue, suggesting that disruption of the IL\u20101RI\u2010mediated inflammatory response may attenuate cellular stress, which was associated with significant protection from diet\u2010induced insulin resistance, independent of obesity.<\/jats:p>","DOI":"10.1002\/pmic.200800761","type":"journal-article","created":{"date-parts":[[2009,6,27]],"date-time":"2009-06-27T03:31:41Z","timestamp":1246073501000},"page":"3244-3256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Attenuation of inflammation and cellular stress\u2010related pathways maintains insulin sensitivity in obese type I interleukin\u20101 receptor knockout mice on a high\u2010fat diet"],"prefix":"10.1002","volume":"9","author":[{"given":"Baukje","family":"de Roos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Rungapamestry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry","family":"Rucklidge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Horgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinead","family":"Toomey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Browne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E.","family":"Loscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kingston H. 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