{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:56:37Z","timestamp":1787064997193,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2009,7,24]],"date-time":"2009-07-24T00:00:00Z","timestamp":1248393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Endocore Research Trust"},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Foundation for Research, Science and Technology of New Zealand"},{"DOI":"10.13039\/501100001518","name":"Maurice & Phyllis Paykel Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001518","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009940","name":"New Zealand Lottery Grants Board","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009940","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001511","name":"Auckland Medical Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001511","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001537","name":"University of Auckland","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001537","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to identify new diabetic nephropathy (DN)\u2010related proteins and renal targets of the copper(II)\u2010selective chelator, triethylenetetramine (TETA) in streptozotocin\u2010diabetic rats. We used the recently developed iTRAQ\u2122 technology to compare renal protein profiles among non\u2010diabetic, diabetic, and TETA\u2010treated diabetic rats. In diabetic kidneys, tubulointerstitial nephritis antigen (TINag), voltage\u2010dependent anion\u2010selective channel (VDAC) 1, and VDAC2 were up\u2010regulated in parallel with alterations in expression of proteins with functions in oxidative stress and oxidative phosphorylation (OxPhos) pathways. By contrast, mitochondrial HSP 60, Cu\/Zn\u2010superoxide dismutase, glutathione\n                    <jats:italic>S<\/jats:italic>\n                    \u2010transferase \u03b13 and aquaporin\u20101 were down\u2010regulated in diabetic kidneys. Following TETA treatment, levels of\n                    <jats:sc>D<\/jats:sc>\n                    \u2010amino acid oxidase\u20101, epoxide hydrolase\u20101, aquaporin\u20101, and a number of mitochondrial proteins were normalized, with concomitant amelioration of albuminuria. Changes in levels of TINag, collagen VI\u03b11, actinin 4\u03b1, apoptosis\u2010inducing factor 1, cytochrome\n                    <jats:italic>C<\/jats:italic>\n                    , histone H3, VDAC1, and aquaporin\u20101 were confirmed by Western blotting or immunohistochemistry. Changes in expression of proteins related to tubulointerstitial function, podocyte structure, and mitochondrial apoptosis are implicated in the mechanism of DN and their reversal by TETA. These findings are consistent with the hypothesis that this new experimental therapy may be useful for treatment of DN.\n                  <\/jats:p>","DOI":"10.1002\/pmic.200900285","type":"journal-article","created":{"date-parts":[[2009,7,24]],"date-time":"2009-07-24T05:53:50Z","timestamp":1248414830000},"page":"4309-4320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Quantitative proteomic profiling identifies new renal targets of copper(II)\u2010selective chelation in the reversal of diabetic nephropathy in rats"],"prefix":"10.1002","volume":"9","author":[{"given":"Deming","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Middleditch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangdong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greeshma","family":"Vazhoor Amarsingh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katya","family":"Ruggiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony R. 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