{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:52:38Z","timestamp":1791197558815,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2010,5,4]],"date-time":"2010-05-04T00:00:00Z","timestamp":1272931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"crossref","award":["30530140"],"award-info":[{"award-number":["30530140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Basic Project of Ministry of Science and Technology of China","award":["2007FY210800"],"award-info":[{"award-number":["2007FY210800"]}]},{"name":"China Specific Project for Developing New Drugs","award":["2009ZX09103-612"],"award-info":[{"award-number":["2009ZX09103-612"]}]},{"name":"China Specific Project for Developing New Drugs","award":["2008ZX10001-015-9"],"award-info":[{"award-number":["2008ZX10001-015-9"]}]},{"DOI":"10.13039\/501100012166","name":"973 Program","doi-asserted-by":"crossref","award":["2010CB529800"],"award-info":[{"award-number":["2010CB529800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"973 Program","doi-asserted-by":"crossref","award":["2007CB914204"],"award-info":[{"award-number":["2007CB914204"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Changjiang Scholars and Innovative Research University Program","award":["IRT0745"],"award-info":[{"award-number":["IRT0745"]}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Scorpion venoms contain a vast untapped reservoir of natural products, which have the potential for medicinal value in drug discovery. In this study, toxin components from the scorpion <jats:italic>Heterometrus petersii<\/jats:italic> venom were evaluated by transcriptome and proteome analysis. Ten known families of venom peptides and proteins were identified, which include: two families of potassium channel toxins, four families of antimicrobial and cytolytic peptides, and one family from each of the calcium channel toxins, La1\u2010like peptides, phospholipase A2, and the serine proteases. In addition, we also identified 12 atypical families, which include the acid phosphatases, diuretic peptides, and ten orphan families. From the data presented here, the extreme diversity and convergence of toxic components in scorpion venom was uncovered. Our work demonstrates the power of combining transcriptomic and proteomic approaches in the study of animal venoms.<\/jats:p>","DOI":"10.1002\/pmic.200900763","type":"journal-article","created":{"date-parts":[[2010,5,4]],"date-time":"2010-05-04T22:37:48Z","timestamp":1273012668000},"page":"2471-2485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Molecular diversity of toxic components from the scorpion <i>Heterometrus petersii<\/i> venom revealed by proteomic and transcriptome analysis"],"prefix":"10.1002","volume":"10","author":[{"given":"Yibao","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingliang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.242735499"},{"key":"e_1_2_6_3_2","volume-title":"The Biology of Scorpions","author":"David W. S.","year":"1990"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2008.05.021"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.156"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1357"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802054200"},{"key":"e_1_2_6_8_2","first-page":"580","article-title":"Imaging glioma extent with 131I\u2010TM\u2010601","volume":"46","author":"Hockaday D. C.","year":"2005","journal-title":"J. Nucl. Med."},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00542-08"},{"key":"e_1_2_6_10_2","first-page":"1","article-title":"High\u2010level systematics and phylogeny of the extant scorpions (Scorpiones: Orthosterni)","volume":"11","author":"Michael E. S.","year":"2003","journal-title":"Euscorpius"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00854-1"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2002.03726.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2004.10.018"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm832"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200500525"},{"key":"e_1_2_6_16_2","first-page":"290","article-title":"Transcriptome analysis of the venom gland of the scorpion Scorpiops jendeki: implication for the evolution of the scorpion venom arsenal","volume":"10","author":"Ma Y.","year":"2009","journal-title":"Biomed. Chromatogr. Genomics"},{"key":"e_1_2_6_17_2","first-page":"119","article-title":"Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones)","volume":"8","author":"Schwartz E. F.","year":"2007","journal-title":"Biomed. Chromatogr. Genomics"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200700948"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.24.4876"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.415"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.01.020"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2004.03.022"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1720574"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5200-6"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20041705"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111258200"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(00)00160-4"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-1044fje"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr1000016"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2004.02.005"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.24.12185"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00147.x"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-3106-8"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2007.10.004"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01384-3"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7370-x"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-004-4149-1"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.09.003"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5472"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.03177.x"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3590035"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01556.x"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2009.04.010"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100216200"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2007.04.012"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.2009.00863.x"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2007.03.007"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi0349930"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.18.11886"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2008.06.003"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.3109\/15569549609080106"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)52245-6"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200800499"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1076181"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/355827a0"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-006-9123-z"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msg126"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M700094-MCP200"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2009.11.010"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2009.05.005"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.09.006"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.2004.04439.x"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.9.081307.164356"}],"container-title":["PROTEOMICS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpmic.200900763","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpmic.200900763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmic.200900763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:23:24Z","timestamp":1761056604000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pmic.200900763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":62,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1002\/pmic.200900763"],"URL":"https:\/\/doi.org\/10.1002\/pmic.200900763","archive":["Portico"],"relation":{},"ISSN":["1615-9853","1615-9861"],"issn-type":[{"value":"1615-9853","type":"print"},{"value":"1615-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"2009-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-07-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}