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We carried out proteome profiling of peripheral blood mononuclear cells (PBMCs) and serum from BD patients who were not experiencing mania or major depression (euthymia) compared to matched healthy controls using liquid chromatography\u2013mass spectrometry (LC\u2010MS\n                    <jats:sup>E<\/jats:sup>\n                    ) and Multi\u2010Analyte Profiling (Human Map\n                    <jats:sup>\u00ae<\/jats:sup>\n                    ) platforms. This resulted in the identification of approximately 60 differentially expressed molecules involved predominantly in cell death\/survival pathways. In PBMCs, this was manifested in cytoskeletal and stress response\u2010associated proteins, whereas most serum analytes were associated with the inflammatory response. The predicted effect of serum analytes on physiological systems was tested by treating PBMCs with serum obtained from the same patients, resulting in reduced cellular survival. These preliminary results suggest that BD patients carry a peripheral fingerprint that has detrimental effects on cell function and that could be used to distinguish BD patients from healthy controls despite being in a remission phase. It is hoped that additional studies of BD patients in the manic and depressed stages could lead to the identification of a molecular fingerprint that could be used for predicting episodic switching and for guiding treatment strategies.\n                  <\/jats:p>","DOI":"10.1002\/pmic.201000291","type":"journal-article","created":{"date-parts":[[2010,11,25]],"date-time":"2010-11-25T08:13:50Z","timestamp":1290672830000},"page":"94-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Peripheral profiling analysis for bipolar disorder reveals markers associated with reduced cell survival"],"prefix":"10.1002","volume":"11","author":[{"given":"Marlis","family":"Herberth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Koethe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishai","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia D.","family":"Krzyszton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Schoeffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermelindis","family":"Ruh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Rahmoune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kranaster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Schoenborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus F.","family":"Leweke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Guest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Bahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.20013"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.147.9.1194"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2005.tb00026.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.08.012"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00665.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.5694\/j.1326-5377.2007.tb01328.x","article-title":"Early intervention in bipolar disorders: opportunities and pitfalls","volume":"187","author":"Berk M.","year":"2007","journal-title":"Med. 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