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Substantial differences exist between the proteomes of WT and APP\/PS\u20101 mice at 9 or 12 months, indicating that A\u03b2 deposition and oxidative stress lead to downstream changes in protein expression. Altered proteins are involved in energy\u2010related pathways, excitotoxicity, cell cycle signaling, synaptic abnormalities, and cellular defense and structure. Overall, the proteomic results support the notion that NAC may be beneficial for increasing cellular stress responses in WT mice and for influencing the levels of energy\u2010 and mitochondria\u2010related proteins in APP\/PS\u20101 mice.<\/jats:p>","DOI":"10.1002\/pmic.201000523","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:56:24Z","timestamp":1314838584000},"page":"4243-4256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Proteomic analysis of brain proteins in APP\/PS\u20101 human double mutant knock\u2010in mice with increasing amyloid \u03b2\u2010peptide deposition: Insights into the effects of in vivo treatment with <i>N<\/i>\u2010acetylcysteine as a potential therapeutic intervention in mild cognitive impairment and Alzheimer's disease"],"prefix":"10.1002","volume":"11","author":[{"given":"Ren\u00e3 A. 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