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The best investigated member of this group of almost seventy species is <jats:italic>Corynebacterium glutamicum<\/jats:italic>, a soil bacterium isolated in 1957, which is used for the industrial production of more than two million tons of amino acids per year. This review focuses on the technical advances made in proteomics approaches during the last years and summarizes applications of these techniques with respect to <jats:italic>C. glutamicum<\/jats:italic> metabolic pathways and stress response. 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