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The tyrosine kinase product of the Philadelphia chromosome, P210 BCR\u2010ABL, provided a pathogenetic explanation for the initiation of the CML chronic phase and is the molecular therapeutic target for the disease. Imatinib mesylate, an orally available BCR\u2010ABL kinase inhibitor, can induce haematologic and cytogenetic remission of CML. However, imatinib resistance occurs frequently, resulting in relapse. New treatment strategies are focusing on resistant CML stem cells and the bone marrow stroma. The identification of novel pathways and mechanisms in the bone marrow microenvironment could significantly contribute to the development of such strategies. In this work, we used a high\u2010resolution label\u2010free MS<jats:sup>E<\/jats:sup> proteomic approach to identify differential protein expression in the CML bone marrow plasma of responsive and resistant patients. Oxidative lipid metabolism and regulation of the switch from canonical to noncanonical WNT signaling may contribute to CML resistance in the bone marrow compartment.<\/jats:p>","DOI":"10.1002\/pmic.201200066","type":"journal-article","created":{"date-parts":[[2012,7,4]],"date-time":"2012-07-04T18:41:21Z","timestamp":1341427281000},"page":"2618-2631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Label\u2010free MS<sup>E<\/sup> proteomic analysis of chronic myeloid leukemia bone marrow plasma: disclosing new insights from therapy resistance"],"prefix":"10.1002","volume":"12","author":[{"given":"Luciana","family":"Pizzatti","sequence":"first","affiliation":[{"name":"Divis\u00e3o de Laborat\u00f3rios do CEMO Instituto Nacional do C\u00e2ncer  Rio de Janeiro Brazil"},{"name":"Rede Prote\u00f4mica do Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Panis","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Laborat\u00f3rios do CEMO Instituto Nacional do C\u00e2ncer  Rio de Janeiro Brazil"},{"name":"Laborat\u00f3rio de Fisiopatologia de Radicais Livres UEL  Londrina PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Lemos","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Laborat\u00f3rios do CEMO Instituto Nacional do C\u00e2ncer  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mois\u00e9s","family":"Rocha","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Laborat\u00f3rios do CEMO Instituto Nacional do C\u00e2ncer  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubens","family":"Cecchini","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiopatologia de Radicais Livres UEL  Londrina PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo H. 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