{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:55:27Z","timestamp":1761162927874,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T00:00:00Z","timestamp":1357862400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>\n                    Autosomal dominant polycystic kidney disease (\n                    <jats:styled-content style=\"fixed-case\">ADPKD<\/jats:styled-content>\n                    ) is an inheritable and progressive kidney disease featured by the formation of fluid\u2010filled cysts. In a previous study, transgenic mice overexpressing human\n                    <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content>\n                    2 gene were produced as an\n                    <jats:styled-content style=\"fixed-case\">ADPKD<\/jats:styled-content>\n                    animal model. To select genes controlled by\n                    <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content>\n                    2, 2\n                    <jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>\n                    was performed using kidney tissues of 12\u2010 and 18\u2010month\u2010old transgenic mice. The protein localization was detected by immunohistochemistry, and 3\n                    <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\n                    culture was utilized to observe in vitro cystogenesis. As a result,\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\n                    <\/jats:italic>\n                    \u2010myc downstream\u2010regulated gene 1 (\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">NDRG<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    ) was chosen as a candidate regulator gene of cystogenesis.\n                    <jats:styled-content style=\"fixed-case\">NDRG<\/jats:styled-content>\n                    1 is an intracellular protein involved in cellular proliferation and differentiation. This gene was expressed much higher in the kidney of\n                    <jats:italic>\n                      h\n                      <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content>\n                      2\n                    <\/jats:italic>\n                    <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                    mice. Also, the high level of\n                    <jats:styled-content style=\"fixed-case\">NDRG<\/jats:styled-content>\n                    1 protein was detected in the cyst lining epithelial cells. The hypothesis that\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content>\n                      2\n                    <\/jats:italic>\n                    gene regulates\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">NDRG<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    expression was supported, and\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">NDRG<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    knockdown resulted in attenuation of cyst growth in vitro. Furthermore,\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">NDRG<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    knockdown suppressed cellular growth in mouse inner medullary collecting duct\u20103 cells. We found that early growth response 1, a transcription factor that binds to the\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">NDRG<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    promoter, was mediated in the\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">NDRG<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    expression regulation by\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">PKD<\/jats:styled-content>\n                      2\n                    <\/jats:italic>\n                    . In this study, we found the novel gene that was involved in cystogenesis, which will provide the new insight in\n                    <jats:styled-content style=\"fixed-case\">ADPKD<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/pmic.201200248","type":"journal-article","created":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T15:19:39Z","timestamp":1354634379000},"page":"134-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>\n                      <scp>N<\/scp>\n                    <\/i>\n                    \u2010myc downstream\u2010regulated gene 1 is involved in the regulation of cystogenesis in transgenic mice overexpressing human\n                    <scp>PKD<\/scp>\n                    2 gene"],"prefix":"10.1002","volume":"13","author":[{"given":"Bo Hye","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biological Science Sookmyung Women's University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biological Science Sookmyung Women's University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Hyun","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Biological Science Sookmyung Women's University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Mi","family":"Choi","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Biology and Genomics College of Veterinary Medicine Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yona","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Biology and Genomics College of Veterinary Medicine Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je kyung","family":"Seong","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Biology and Genomics College of Veterinary Medicine Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biological Science Sookmyung Women's University Seoul Republic of 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