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In this work, we employed 2<jats:styled-content style=\"fixed-case\">D DIGE<\/jats:styled-content>, followed by <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> identification, to analyze the response of tomato plants infected by <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>itrus exocortis viroid<\/jats:italic> (<jats:styled-content style=\"fixed-case\">CEV<\/jats:styled-content>d). Among the differentially expressed proteins detected, 45 were successfully identified and classified into different functional categories. Validation results by <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> allowed us to classify the proteins into two expression groups. First group included genes with changes at the transcriptional level upon <jats:styled-content style=\"fixed-case\">CEV<\/jats:styled-content>d infection, such as an endochitinase, a \u03b2\u2010glucanase, and pathogenesis\u2010related proteins, <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>10 and <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>69<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>. All these defense proteins were also induced by gentisic acid, a pathogen\u2010induced signal in compatible interactions. The second group of proteins showed no changes at the transcriptional level and included several ribosomal proteins and translation factors, such as the elongation factors 1 and 2 and the translation initiation factor 5\u2010alpha. These results were validated by 2<jats:styled-content style=\"fixed-case\">D W<\/jats:styled-content>estern blot, and possible <jats:styled-content style=\"fixed-case\">PTM<\/jats:styled-content>s caused by <jats:styled-content style=\"fixed-case\">CEV<\/jats:styled-content>d infection were detected. Moreover, an interaction between eukaryotic elongation factor 1 and <jats:styled-content style=\"fixed-case\">CEV<\/jats:styled-content>d was observed by 2<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> Northwestern. The present study provides new protein\u2010related information on the mechanisms of plant resistance to pathogens.<\/jats:p>","DOI":"10.1002\/pmic.201200286","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T15:40:01Z","timestamp":1357746001000},"page":"833-844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["A noncoding plant pathogen provokes both transcriptional and posttranscriptional alterations in tomato"],"prefix":"10.1002","volume":"13","author":[{"given":"Purificaci\u00f3n","family":"Lis\u00f3n","sequence":"first","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular de Plantas Universitat Polit\u00e8cnica de Val\u00e8ncia (UPV) Consejo Superior de Investigaciones Cient\u00edficas (CSIC)  Valencia 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