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We have observed that intestinal tumors are induced in mice fed low\u2010folate diets, and that tumor incidence is increased when these mice also have MTHFR deficiency. This study was undertaken to identify differentially expressed proteins in conditions favoring initial steps of murine carcinogenesis in normal preneoplastic intestine. We compared the proteome of BALB\/c normal intestine in\n                    <jats:italic>\n                      Mthfr\n                      <jats:sup>+\/+<\/jats:sup>\n                    <\/jats:italic>\n                    mice fed control diets for 1 year (low susceptibility to tumorigenesis) with the proteome of\n                    <jats:italic>\n                      Mthfr\n                      <jats:sup>+\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    animals fed low folate diets (higher tumor susceptibility). Our data suggest that the NuRD complex, KRAS\u2010related proteins, the protein synthetic machinery, and fatty acid\u2010related metabolic proteins are upregulated in the early stages of tumorigenesis. These proteins may serve as biomarkers or targets for colorectal cancer diagnosis or therapy.\n                  <\/jats:p>","DOI":"10.1002\/pmic.201400280","type":"journal-article","created":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T19:24:49Z","timestamp":1406834689000},"page":"2558-2565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Quantitative proteomics reveals differentially expressed proteins in murine preneoplastic intestine in a model of intestinal tumorigenesis induced by low dietary folate and MTHFR deficiency"],"prefix":"10.1002","volume":"14","author":[{"given":"Daniel","family":"Leclerc","sequence":"first","affiliation":[{"name":"Department of Human Genetics Montreal Children's Hospital The Research Institute of the McGill University Health Centre McGill University  Montreal Canada"},{"name":"Department of Pediatrics Montreal Children's Hospital The Research Institute of the McGill 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