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Besides non\u2010invasive, simple, and rapid to collect, saliva is a potential source of biomarkers. In this study, we build an SRM assay that targets fourteen OSCC candidate biomarker proteins, which were evaluated in a set of clinically\u2010derived saliva samples. Using Skyline software package, we demonstrated a statistically significant higher abundance of the C1R, LCN2, SLPI, FAM49B, TAGLN2, CFB, C3, C4B, LRG1, SERPINA1 candidate biomarkers in the saliva of OSCC patients. Furthermore, our study also demonstrated that CFB, C3, C4B, SERPINA1 and LRG1 are associated with the risk of developing OSCC. Overall, this study successfully used targeted proteomics to measure in saliva a panel of biomarker candidates for OSCC.<\/jats:p>","DOI":"10.1002\/pmic.201500224","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T04:41:15Z","timestamp":1447130475000},"page":"159-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["A targeted proteomic strategy for the measurement of oral cancer candidate biomarkers in human saliva"],"prefix":"10.1002","volume":"16","author":[{"given":"Rebeca","family":"Kawahara","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Espectrometria de Massas Laborat\u00f3rio Nacional de Bioci\u00eancias LNBio CNPEM  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Bollinger","sequence":"additional","affiliation":[{"name":"Department of Genome Sciences University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Rivera","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Espectrometria de Massas Laborat\u00f3rio Nacional de Bioci\u00eancias LNBio CNPEM  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina P.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo Octavio Frias de Oliveira  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tha\u00eds Bianca","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo Octavio Frias de Oliveira  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana F. 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