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Proteomics has unraveled changes in protein profiling as the result of cell interactions mediated by ligand\/receptor, hormones, soluble factors, and the content of extracellular vesicles. Besides being a brief overview of the main and profitable methodologies now available (evaluating theory behind the methods, their usefulness, and pitfalls), this review focuses on\u2014from a proteome perspective\u2014some signaling pathways and post\u2010translational modifications (PTMs), which are essential for understanding ischemic lesions and their recovery in two vital organs in mammals, the heart, and the kidney. Knowledge of misdirection of the proteome during tissue recovery, such as represented by the convergence between fibrosis and cancer, emerges as an important tool in prognosis. Proteomics of cell\u2013cell interaction is also especially useful for understanding how stem cells interact in injured tissues, anticipating clues for rational therapeutic interventions. In the effervescent field of induced pluripotency and cell reprogramming, proteomic studies have shown what proteins from specialized cells contribute to the recovery of infarcted tissues. Overall, we conclude that proteomics is at the forefront in helping us to understand the mechanisms that underpin prevalent pathological processes.<\/jats:p>","DOI":"10.1002\/pmic.201500341","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T04:40:54Z","timestamp":1447130454000},"page":"328-344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Proteomics of cell\u2013cell interactions in health and disease"],"prefix":"10.1002","volume":"16","author":[{"given":"Rafael S.","family":"Lindoso","sequence":"first","affiliation":[{"name":"Carlos Chagas Filho Institute of Biophysics Federal University of Rio de Janeiro  Rio de Janeiro RJ Brazil"},{"name":"National Institute of Science and Technology for Structural Biology and Bioimaging  Rio de Janeiro RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Sandim","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology for Structural Biology and Bioimaging  Rio de Janeiro RJ Brazil"},{"name":"Leopoldo de Meis Institute of Medical Biochemistry Federal University of Rio de Janeiro  Rio de Janeiro RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Collino","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Molecular Biotechnology Center University of Turin  Turin Italy"},{"name":"Translational Center of Regenerative Medicine University of Turin\/Fresenius Medical Care  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana B.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Carlos Chagas Filho Institute of Biophysics Federal University of Rio de Janeiro  Rio de Janeiro RJ Brazil"},{"name":"National Institute of Science and Technology for Structural Biology and Bioimaging  Rio de Janeiro RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Dias","sequence":"additional","affiliation":[{"name":"National Institute of Cancer  Rio de Janeiro RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milene R.","family":"da Costa","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Federal University of Rio de Janeiro  Rio de Janeiro RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russolina B.","family":"Zingali","sequence":"additional","affiliation":[{"name":"National Institute of Science and Technology for Structural Biology and Bioimaging  Rio de Janeiro RJ Brazil"},{"name":"Leopoldo de Meis Institute of Medical Biochemistry Federal University of Rio de Janeiro  Rio de Janeiro RJ Brazil"},{"name":"Proteomic Network of Rio de Janeiro  Rio de Janeiro RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adalberto","family":"Vieyra","sequence":"additional","affiliation":[{"name":"Carlos Chagas Filho Institute of Biophysics Federal University of Rio de Janeiro  Rio de Janeiro RJ Brazil"},{"name":"National Institute of Science and Technology for Structural Biology and Bioimaging  Rio de Janeiro RJ Brazil"},{"name":"Translational Biomedicine Graduate Program Grand Rio University  Duque de Caxias RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3394"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.278"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2008.11.003"},{"key":"e_1_2_9_5_1","first-page":"256","article-title":"Endocytosis and intracellular processing of transferrin and colloidal gold\u2010transferrin in rat reticulocytes: demonstration of a pathway for receptor shedding","volume":"35","author":"Harding C.","year":"1984","journal-title":"Eur. 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