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To address this, we performed SILAC\u2010based quantitative proteomic analysis on HIV\u2010Tat treated SH\u2010SY5Y neuroblastoma cells. Isolated protein was fractionated by SDS\u2010PAGE and analyzed by nLC\u2010MS\/MS on an Orbitrap Velos. Using MaxQuant, we identified and quantified 3077 unique protein groups, of which 407 were differentially regulated. After applying an additional standard deviation\u2010based cutoff, 29 of these were identified as highly significantly and stably dysregulated. GO term analysis shows dysregulation in both protein translation machinery as well as cytoskeletal regulation that have both been implicated in other dementias. In addition, several key cytoskeletal regulatory proteins such as ARHGEF17, the Rho GTPase, SHROOM3, and CMRP1 are downregulated. 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