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Here, we utilized high\u2010throughput MS to examine the proteomic effects of pID in adulthood on the rat frontal cortex area (FCA). In addition, the FCA proteome was examined in adulthood following risperidone treatment in adolescence to see if these effects could be prevented. We identified 1501 proteins of which 100 were significantly differentially expressed in the FCA at postnatal day 90. Pathway analysis of proteins affected by pID revealed changes in metabolic processes, including the tricyclic acid cycle, mitochondrial dysfunction, and P13K\/Akt signaling. Interestingly, most of these protein changes were not present in the adult pID offspring who received risperidone in adolescence. Considering the link between pID and several neurodevelopmental disorders such as autism and schizophrenia these presented results bring new perspectives to understand the role of iron in metabolic pathways and provide novel biomarkers for future studies of pID.<\/jats:p>","DOI":"10.1002\/pmic.201600407","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:24:57Z","timestamp":1501547097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Effects of Prenatal Iron Deficiency and Risperidone Treatment on the Rat Frontal Cortex:\u2009 A Proteomic Analysis"],"prefix":"10.1002","volume":"17","author":[{"given":"Lorna","family":"Farrelly","sequence":"first","affiliation":[{"name":"Department of Psychiatry Royal College of Surgeons in Ireland Education and Research Centre Beaumont Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Victoria","family":"Rosato\u2010Siri","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, IQUIFIB School of Pharmacy and Biochemistry University of Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"F\u00f6cking","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Royal College of Surgeons in Ireland Education and Research Centre Beaumont Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Codagnone","sequence":"additional","affiliation":[{"name":"De Robertis Institute University of Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Analia","family":"Reines","sequence":"additional","affiliation":[{"name":"De Robertis Institute University of Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Dicker","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology &amp; 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