{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:28:52Z","timestamp":1775024932004,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T00:00:00Z","timestamp":1484697600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201012\u2010BSV6\u20100012\u201001"],"award-info":[{"award-number":["ANR\u201012\u2010BSV6\u20100012\u201001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201014\u2010CE21\u20100006\u201002"],"award-info":[{"award-number":["ANR\u201014\u2010CE21\u20100006\u201002"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>The intentional use by terrorists of biological toxins as weapons has been of great concern for many years. Among the numerous toxins produced by plants, animals, algae, fungi, and bacteria, ricin is one of the most scrutinized by the media because it has already been used in biocrimes and acts of bioterrorism. Improving the analytical toolbox of national authorities to monitor these potential bioweapons all at once is of the utmost interest. MS\/MS allows their absolute quantitation and exhibits advantageous sensitivity, discriminative power, multiplexing possibilities, and speed. In this issue of <jats:italic>Proteomics<\/jats:italic>, Gilquin et\u00a0al. (<jats:italic>Proteomics<\/jats:italic> 2017, <jats:italic>17<\/jats:italic>, 1600357) present a robust multiplex assay to quantify a set of eight toxins in the presence of a complex food matrix. This MS\/MS reference method is based on scheduled SRM and high\u2010quality standards consisting of isotopically labeled versions of these toxins. Their results demonstrate robust reliability based on rather loose scheduling of SRM transitions and good sensitivity for the eight toxins, lower than their oral median lethal doses. In the face of an increased threat from terrorism, relevant reference assays based on advanced proteomics and high\u2010quality companion toxin standards are reliable and firm answers.<\/jats:p>","DOI":"10.1002\/pmic.201600412","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T00:53:02Z","timestamp":1481158382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Striking against bioterrorism with advanced proteomics and reference methods"],"prefix":"10.1002","volume":"17","author":[{"given":"Jean","family":"Armengaud","sequence":"first","affiliation":[{"name":"CEA, DRF, IBiTec\u2010S, SPI, Li2D Laboratory \u201cInnovative technologies for Detection and Diagnostics\u201d  Bagnols\u2010sur\u2010C\u00e8ze France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,18]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins4010015"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.3747"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2016.02.025"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2309"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.4649"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.O114.043968"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac061498b"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins7124854"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200800326"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.3106"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201600357"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2016.07.005"}],"container-title":["PROTEOMICS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpmic.201600412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pmic.201600412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:03:45Z","timestamp":1761048225000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/pmic.201600412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":12,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1002\/pmic.201600412"],"URL":"https:\/\/doi.org\/10.1002\/pmic.201600412","archive":["Portico"],"relation":{},"ISSN":["1615-9853","1615-9861"],"issn-type":[{"value":"1615-9853","type":"print"},{"value":"1615-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2016-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1600412"}}